Results 151 to 160 of about 7,806,372 (301)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

HIV viral suppression in the era of dolutegravir use: Findings from a national survey in Tanzania.

PLoS ONE
BackgroundTanzania has made significant progress in improving access to HIV care and treatment. However, virologic suppression among people living with HIV (PLHIV) has not been fully realized.
Doreen Kamori, Godfrey Barabona, Werner Maokola, Joan Rugemalila, Macdonald Mahiti, Mucho Mizinduko, Amon Sabasaba, George Ruhago, Linda Mlunde, Salim S Masoud, Davis Amani, Erick Mboya, Sabina Mugusi, Anath Rwebembera, George Mgomella, Sarah Asiimwe, Beatrice Mutayoba, Prosper Njau, Takamasa Ueno, Andrea Pembe, Bruno Sunguya   +20 more
doaj   +1 more source

A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae. [PDF]

Sci Adv, 2023
Smidler AL, Pai JJ, Apte RA, Sánchez C HM, Corder RM, Jeffrey Gutiérrez E, Thakre N, Antoshechkin I, Marshall JM, Akbari OS.   +9 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Effects of Maize Density and Sowing Pattern on Weed Suppression and Maize Grain Yield [PDF]

Pesticidi i Fitomedicina, 2007
Plant competition in its basic sense can be defined as competition for resources such as light, water and nutrients. The intensity of crop competition, especially competition of row crops such as maize, mostly depends on population density and plant ...
Milena Simić, Lidija Stefanović
doaj  

Gene drive designs for efficient and localisable population suppression using Y-linked editors. [PDF]

PLoS Genet, 2022
Geci R, Willis K, Burt A.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Trends in population HIV viral suppression: a longitudinal analysis

AIDS
This study examines trends in HIV viral suppression and the impact of age and sex on suppression rates in a rural KwaZulu-Natal (KZN) population-based cohort from 2011 to 2023. Population viral suppression improved over time, peaking at 71% for men and 79% for women in 2022, but declined in 2023 possibly due to COVID-19 ...
Otto, Margot, Okango, Elphas, Mee, Paul, Dobra, Adrian, Tram, Khai Hoan, Gareta, Dickman, Otambo, Wilfred, Moyo, Reuben, Sereo, Tumelo, Blose, Ntombifuthi, Letoao, Nthoesele Shoeshoe, Mupanguri, Letitsia, Mwambi, Henry, Herbst, Kobus, Tanser, Frank   +14 more
openaire   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source