Results 131 to 140 of about 7,572,211 (397)

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Outcomes of Population Surveillance Data Collection Pilots and the Behavioral Risk Factor Surveillance System: What Happens in Texas. [PDF]

Surv Pract, 2023
Kirtland K, Garvin W, Yan T, Cavazos M, Berzofsky M, Freedner N, Muldavin B, Levine B, Gamble S, Town M.   +9 more
europepmc   +1 more source

Invasive Pneumococcal Disease in Solid Organ Transplant Recipients—10‐Year Prospective Population Surveillance

American Journal of Transplantation, 2007
Prospective population‐based surveillance to assess the incidence and impact of invasive pneumococcal disease (IPD) in organ transplant patients is lacking.
Deepali Kumar, A. Humar, Agron Plevneshi, K. Green, G. Prasad, D. Siegal, A. McGeer   +6 more
semanticscholar   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

Diabetes Care in Iran: Where We Stand and Where We Are Headed

Annals of Global Health, 2016
Background: The prevalence of diabetes has steadily increased in Iran from the time of the first published nationally representative survey in 1999 and despite efforts and strategies to reduce disease burden. Objectives: The aim of the present review was
Sina Noshad, Mohsen Afarideh, Behnam Heidari, Jeffrey I. Mechanick, Alireza Esteghamati   +4 more
doaj   +1 more source

Testing the protein-leverage hypothesis using population surveillance data. [PDF]

R Soc Open Sci, 2022
Senior AM, Raubenheimer D, Simpson SJ.
europepmc   +1 more source

Firsthand Opiates Abuse on Social Media: Monitoring Geospatial Patterns of Interest Through a Digital Cohort [PDF]

, 2019
In the last decade drug overdose deaths reached staggering proportions in the US. Besides the raw yearly deaths count that is worrisome per se, an alarming picture comes from the steep acceleration of such rate that increased by 21% from 2015 to 2016 ...
Bajardi, Paolo, Balsamo, Duilio, Panisson, André   +2 more
core   +2 more sources

Choroid Plexus Fibroblast–ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury

Advanced Science, EarlyView.
This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong   +10 more
wiley   +1 more source

Putting health facilities on the map: a renewed call to create geolocated, comprehensive, updated, openly licensed dataset of health facilities in sub-Saharan African countries

BMC Medicine
Background Healthcare service provision, planning, and management depend on the availability of a geolocated, up-to-date, comprehensive health facility database (HFDB) to adequately meet a population’s healthcare needs. HFDBs are an integral component of
Peter M. Macharia, Lenka Beňová, Nicolas Ray, Aline Semaan, Moses M. Musau, John Kapoi Kipterer, Mark Herringer, Robert W. Snow, Emelda A. Okiro   +8 more
doaj   +1 more source

Sampling Methods in Clinical Research; an Educational Review

Archives of Academic Emergency Medicine, 2017
Clinical research usually involves patients with a certain disease or a condition. The generalizability of clinical research findings is based on multiple factors related to the internal and external validity of the research methods.
Mohamed Elfil, Ahmed Negida
doaj   +1 more source