Results 181 to 190 of about 536,545 (247)

Population surveillance of navigation frequency and palliative care contact before death among cancer patients. [PDF]

Can Oncol Nurs J, 2019
Johnston GM, Park G, Urquhart R, Walsh G, McCallum M, Rigby K.   +5 more
europepmc   +1 more source

Breast Cancer in Native American Women: A Population Based Outcomes Study involving 863,958 Patients from the Surveillance Epidemiology and End Result (SEER) Database (1973-2010)

Sambasivam Gopinath, Swarna gowri
openalex   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Estimating age-stratified influenza-associated invasive pneumococcal disease in England: A time-series model based on population surveillance data. [PDF]

PLoS Med, 2019
Chiavenna C, Presanis AM, Charlett A, de Lusignan S, Ladhani S, Pebody RG, De Angelis D.   +6 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Population surveillance of cardiovascular diseases in low-income to middle-income countries should leverage existing international collaborations. [PDF]

BMJ Glob Health, 2018
Echouffo-Tcheugui JB, Yaya S, Joshi R, Narayan KMV, Kengne AP.   +4 more
europepmc   +1 more source

City-wide Surveillance for the Occurrence of Respiratory Syncytial Virus(RSV) Respiratory Tract Infections in a Population of High Risk Infants ≤32 weeks Gestational Age † 1453 [PDF]

, 1998
Janine Y. Khan, Beverly Brozanski
openalex   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

A prediction model for neonatal mortality in low- and middle-income countries: an analysis of data from population surveillance sites in India, Nepal and Bangladesh. [PDF]

Int J Epidemiol, 2019
Houweling TAJ, van Klaveren D, Das S, Azad K, Tripathy P, Manandhar D, Neuman M, de Jonge E, Been JV, Steyerberg E, Costello A.   +10 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source