Results 101 to 110 of about 2,135,400 (251)

Star Clusters in the Nearby Late-Type Galaxy NGC 1311

open access: yes, 2007
Ultraviolet, optical and near infrared images of the nearby (D ~ 5.5 Mpc) SBm galaxy NGC 1311, obtained with the Hubble Space Telescope, reveal a small population of 13 candidate star clusters.
Ashman K. M. & Zepf S. E.   +14 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

From Locational Fundamentals to Increasing Returns: The Spatial Concentration of Population in Spain, 1787-2000 [PDF]

open access: yes
Does population follow the same inverted-U pattern of concentration/dispersion that has been found in the case of economic activity in the long run? In this paper we present the evidence for eight European countries during the nineteenth and twentieth ...
Fernando Collantes   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Have Biotech Seeds Increased Maize Yields? [PDF]

open access: yes
Corn yield is determined by soils, weather, seed used and other technology choices. Global population and per capita income growth trends as well as demand from the energy sector have placed great stress on cropland use.
Hennessy, David A.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Abundance, Distribution and Population Trends of Waterbirds in the Usangu Wetland: A Biodiversity Hotspot Threatened by Human Activities

open access: yesEcology and Evolution
Waterbirds play essential ecological function contributing to maintenance of species diversity, pest control, seed dispersal, and vectors for invertebrates. Approximately one‐third of the waterbird assemblage inhabits wetland environments.
Amani Chaula   +2 more
doaj   +1 more source

THREATENED MEDICINAL PLANTS OF UKRAINE: AN ASSESSMENT OF THE CURRENT PROTECTION STATUS [PDF]

open access: yesJournal of Plant Development, 2017
More than 2 200 vascular species of Ukraine were investigated as medicinal plants, containing biologically active substances which are used at present or can be used in the future for medicinal purposes, including production of commercial drugs.
Valentyna M. MINARCHENKO
doaj  

The brain drain and the world distribution of income and population [PDF]

open access: yes, 2007
This paper models the evolution of the world distribution of income and shows that while the distribution of income per capita across economies in the world will be stable in the long run, the world distribution of population may be divergent.
Mountford, A., Rapoport, H.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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