Sensitive detection systems for infectious agents in xenotransplantation*
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Effects of Porcine Circovirus Type 2 (PCV2) Maternal Antibodies on Experimental Infection of Piglets with PCV2 [PDF]
ABSTRACTTo determine the effects of porcine circovirus type 2 (PCV2) maternal antibodies on and response to experimental PCV2 infection, 24 piglets were divided into four groups on the basis of the enzyme-linked immunosorbent assay titers of PCV2 maternal antibodies: group A (n= 6; sample/positive [S/P] ratio, <0.2), group B (n= 5;S/Pratio, >0.2 ...
McKeown, N.E. +7 more
openaire +3 more sources
Revisiting the taxonomical classification of Porcine Circovirus type 2 (PCV2) [PDF]
PCV2 has emerged as one of the most devastating viral infections of swine farming, causing a relevant economic impact due to direct losses and control strategies expenses. Epidemiological and experimental studies have evidenced that genetic diversity is potentially affecting the virulence of PVC2. The growing number of PCV2 complete genomes and partial
Franzo, Giovanni|| +7 more
openaire +4 more sources
Porcine circovirus type 2 (PCV2), which is a member of the Circovirus genus in the family of Circoviridae, is a small non-enveloped, closed-circular ssDNA.
Vassakorn KHOPHLOIKLANG +8 more
doaj +1 more source
Field Evaluation of a Novel Combined Vaccine Against Porcine Circovirus Types 2a/d, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis With an Emphasis on Growth Performance. [PDF]
A field trial on three commercial farms evaluated a combined vaccine targeting PCV2a/d, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Vaccinated pigs showed improved average daily weight gain, stronger immune responses against these pathogens, and significantly reduced viral and mycoplasmal loads and lesion severity, supporting its efficacy under
Suh J +7 more
europepmc +2 more sources
Immunology of porcine circovirus type 2 (PCV2)
The emergence of porcine circovirus type 2 (PCV2) associated diseases and particularly postweaning multisystemic wasting syndrome (PMWS) was a shock for the swine industry and formulated a considerable challenge for researchers in the area of viral immunology in swine. The unique features of PMWS of which emaciation and lymphoid depletion were the most
Laila, Darwich, Enric, Mateu
openaire +2 more sources
Vimentin promotes porcine circovirus type 2 (PCV2) replication in pig alveolar macrophage
Porcine circovirus type 2 (PCV2) is a swine pathogen that causes postweaning multisystemic wasting syndrome, associated with a number of other disease symptoms in pigs. It has caused high economic losses for pig industries in China and worldwide. Vimentin is a cytoskeletal protein involved in the lifecycle of numerous viruses.
Yanni Gao +6 more
openaire +3 more sources
Preclinical detection of porcine circovirus type 2 infection using an ultrasensitive nanoparticle DNA probe-based PCR assay. [PDF]
Porcine circovirus type 2 (PCV2) has emerged as one of the most important pathogens affecting swine production globally. Preclinical identification of PCV2 is very important for effective prophylaxis of PCV2-associated diseases.
Yong Huang +6 more
doaj +1 more source
An epidemiological investigation of porcine circovirus type 2 and porcine circovirus type 3 infections in Tianjin, North China [PDF]
Novel porcine circovirus type 3 (PCV3), first identified in the United States, has been detected in many other countries. Porcine circovirus is associated with postweaning multisystemic wasting syndrome, reproductive failure, congenital tremors, and ...
Shuai-Yong Wang +14 more
doaj +2 more sources
Epidemiology and transmission of porcine circovirus type 2 (PCV2)
PCV2 has been highly prevalent in the pig population for decades, prior to the emergence of associated clinical disease manifestations that severely affected the pig production worldwide in the late 90s. PCV2 can be further subdivided into several genotypes.
Nicolas, Rose +3 more
openaire +2 more sources

