Results 191 to 200 of about 78,388 (268)

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Docosahexaenoic acid alleviates cell injury and improves barrier function by suppressing necroptosis signalling in TNF-α-challenged porcine intestinal epithelial cells. [PDF]

Innate Immun, 2020
Xiao K, Xu Q, Liu C, He P, Qin Q, Zhu H, Zhang J, Gin A, Zhang G, Liu Y.   +9 more
europepmc   +1 more source

Tumour‐targeted fluorescence‐guided surgery in gastrointestinal cancer: A systematic review of preclinical and clinical research

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Tumour‐targeted fluorescence‐guided surgery (Ttfgs) enhances intraoperative precision in gastrointestinal cancer treatment. Translation of (Ttfgs) into clinical practice is limited by heterogeneity, regulatory hurdles, biomarker variability and absence of phase III trials.
Aaya Darai, Evie H. M. Graus, Femke J. A. van der Stroom, Mark Rijpkema, Alexander Vahrmeijer, Denise E. Hilling, Johannes H. W. De Wilt, Merlijn Hutteman   +7 more
wiley   +1 more source

pH‐Responsive Sodium Alginate Micro‐Nano Hydrogels for Oral Insulin Delivery: Enhancing Therapeutic Efficacy and Reducing Hypoglycemic Risk

Food Frontiers, Volume 7, Issue 2, March 2026.
Schematic illustration of pH‐responsive SC@AP@INS for oral insulin delivery. (A) pH‐responsive mechanism of sodium alginate‐based hydrogels. (B) Preparation of drug‐loaded microsphere gel via the electrospray method. The controlled release of drug‐loaded micelles in the colon enhances insulin delivery efficiency while minimizing systemic exposure and ...
Minghui Kong, Haixia Yang, Daidi Fan, Jianjun Deng   +3 more
wiley   +1 more source

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation. [PDF]

Virus Res
Li Z, Chen X, Ma C, Du X, Zhang Y.
europepmc   +1 more source

Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets

Food Frontiers, Volume 7, Issue 2, March 2026.
After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao, Xinyi Tian, YiKun Li, Jie Zhang, Hongcan Huang, Yu‐Xuan Lyu, Baichuan Deng   +6 more
wiley   +1 more source

Modulation of in Vitro Digestibility and Bioaccessibility in Aging‐Related Gastrointestinal Models: Effects of Pork Processing Methods

Food Frontiers, Volume 7, Issue 2, March 2026.
Simulated elderly digestion showed markedly lower efficiency than adults. SV processing enhanced peptide release and bioaccessibility, and counteracted the reduced digestive efficiency of the EA model. ABSTRACT This study investigated how gastrointestinal (GI) changes in elderly achlorhydria individuals (EA) affect protein digestibility and peptide ...
Xiangyue Cao, Ruiqi He, Dan Yan, Fan Zhao, Shijie Ding, Haoxi Liu, Chong Wang, Guanghong Zhou   +7 more
wiley   +1 more source

The Dietary Polyphenol Resveratrol in Intestinal Ischemia–Reperfusion Injury: From Multifaceted Protective Mechanisms to Clinical Translation Challenges

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Intestinal ischemia–reperfusion (I/R) injury is a life‐threatening condition with mortality approaching 50%, driven by oxidative stress, inflammatory cascades, ferroptosis, and intestinal barrier disruption that ultimately precipitates distant organ dysfunction.
Xue‐feng Zhang, Zhi Huang, Yuan Zeng, Yan Zhang, Ping Li, Fei‐xiang Wang, Liang Nie   +6 more
wiley   +1 more source

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity

Glia, Volume 74, Issue 3, March 2026.
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert, Joana Paes de Faria, Olaf Jahn, Ege Bilgin, Nikola Łukasik, Chethana Rao, Mišo Mitkovski, Fritz Benseler, Nils Brose, Sophie B. Siems, Sandra Goebbels, Wiebke Möbius, Helge Ewers, João B. Relvas, Hauke B. Werner   +14 more
wiley   +1 more source