Results 111 to 120 of about 8,129,869 (250)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Subsoiling tillage increases water-use efficiency of winter wheat by improving soil hydraulic properties associated with pore structure in the North China Plain

Crop Journal
Subsoiling is widely used to improve soil productivity in the North China Plain (NCP). However, its effects on pore network-based hydraulic properties and their relationship with water use efficiency (WUE) are far from clear.
Meng Yuan, Xiudi Shangguan, Xin Wang, Shiyu Wei, Bowen Li, Zhendong Liu, Rui Zong, Yanli Fan, Quanqi Li   +8 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Pore pressure prediction based on conventional well logs and seismic data using an advanced machine learning approach

Journal of Rock Mechanics and Geotechnical Engineering
Pore pressure is a decisive measure to assess the reservoir’s geomechanical properties, ensures safe and efficient drilling operations, and optimizes reservoir characterization and production.
Muhsan Ehsan, Umar Manzoor, Rujun Chen, Muyyassar Hussain, Kamal Abdelrahman, Ahmed E. Radwan, Jar Ullah, Muhammad Khizer Iftikhar, Farooq Arshad   +8 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Validation of pore network modeling for determination of two-phase transport in fibrous porous media. [PDF]

Sci Rep, 2020
Huang X, Zhou W, Deng D.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Pore-scale network modeling of Ellis and Herschel-Bulkley fluids

, 2014
Network modeling is used to study the flow in porous media of Ellis and Herschel–Bulkley fluids, which model a large group of time-independent non-Newtonian fluids. Previous work is extended to include yield-stress and shear-thickening phenomena.
Taha Sochi (680272)
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source