Results 61 to 70 of about 39,029 (254)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

4D physics-based pore pressure monitoring in the shallow subsurface of Groningen, the Netherlands

, 2022
<p>We previously developed a physics-based model relating changes in pore pressure and vertical stress to seismic velocity variations and validated the model in a small area of Groningen gas field. Using the entire Groningen seismic network, near-surface velocity changes are estimated over a three-year period, using passive image ...
Eldert Fokker, Elmer Ruigrok, Rhys Hawkins, Jeannot Trampert   +3 more
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

An Experimental and Modeling Study on the Response to Varying Pore Pressure and Reservoir Fluids in the Morrow A Sandstone

International Journal of Geophysics, 2012
In mature oil fields undergoing enhanced oil recovery methods, such as CO2 injection, monitoring the reservoir changes becomes important. To understand how reservoir changes influence compressional wave (P) and shear wave (S) velocities, we conducted ...
Aaron V. Wandler, Thomas L. Davis, Paritosh K. Singh   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Design and manufacturing of supercritical drying autoclave for aerogel production

Iraqi Journal of Physics, 2019
This article will address autoclave design considerations and manufacturing working with high pressure low temperature supercritical drying technique to produce silica aerogel.
Ashraf M. Alattar
doaj   +1 more source

New technology of fiber leakage monitoring in long-distance water transfer channels in alpine and cold regions

Yantu gongcheng xuebao, 2020
In the seepage monitoring of long-distance water transfer channels, the traditional monitoring technology has obvious shortcomings. Based on the principles of Raman optical time domain reflection, a new type of seepage monitoring optical cableh is ...
LI Deng-hua 1, ZHANG Gui-rong 1, DING Yong 2, KONG Yang 1, HE Ning 3
doaj   +1 more source

THE IMPULSE RESPONSE FUNCTION ANALYSIS OF PORE PRESSURES MONITORING DATA

, 2007
Effective control of dam safety requires that the measured pore-pressure data be interpreted in the shortest possible time following the readings. Direct resolution based on partial differential equations are not appropriate. We present a relevant formalism for analysing pore-pressure monitoring data: the Impulse Response Function Analysis (IRFA ...
Bonelli, Stéphane, Radzicki, Krzysztof
openaire   +1 more source