Results 81 to 90 of about 39,029 (254)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Evaluation of multi-scale pore and fracture stress sensitivity in coal based on low field NMR technique

Meikuang Anquan
Coal seam water injection is a widely used fully mechanized mining method for dust suppression. The pore structure and stress state change when water pressure acts on the coal during water injection, but the pore structure is the primary factor affecting
Liren LIU, Xiaotao ZHANG, Zhixin WANG
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Field tests on excess pore pressure and soil pressure of pile-soil interface for a single pile during pile-sinking in clay

Yantu gongcheng xuebao, 2019
Stress change of pile-soil interface for jacked-in piles during pile-sinking in clay is a topic of concern in the geotechnical engineering. A full-scale jacked-in pile is penetrated into the clay in Dongying city of China and studied by monitoring the ...
WANG Yong-hong 1,2, ZHANG Ming-yi 1,2, LIU Jun-wei 1,2, BAI Xiao-yu 1,2, YANG Su-chun 1, SANG Song-kui 1, YAN Nan 3
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Study on Ultrasonic Characteristics and Prediction of Rock with Different Pore Sizes

Shock and Vibration
The internal defects of rocks are the main cause of instability and failure in underground engineering. Therefore, using ultrasonic monitoring technology to study the defect characteristics of rocks containing voids is of great significance. The research
Lei Wang, Wen Nie, Ming Xie, Zi Wang, Wei Lu, Dongmei Chen, Weinan Lin   +6 more
doaj   +1 more source

Studies of in Situ Pore Pressure Fluctuations At Various Scales Études des fluctuations in situ de la pression de pore à différentes échelles

Oil & Gas Science and Technology, 2006
Pore pressure fluctuations in fluid saturated geological formations, either of natural or anthropogenic origin, can be observed at different scales. Natural fluctuations, e. g.
Kümpel H. J., Grecksch G., Lehmann K., Rebscher D., Schulze K. C.   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Experimental Investigation of Permeability Sensitivity of Coal Reservoir to Reservoir Pressure and Its Fluid–Solid Coupling Control Mechanism

Energies
During coalbed methane (CBM) production, coal reservoir pore/fracture structure varies dynamically under the action of fluid–solid coupling. And coal reservoir permeability changes accordingly.
Xiaokai Xu, Yue Xin, Qingchao Li, Shuo Zhang, Lin Tian, Zhengzheng Xue   +5 more
doaj   +1 more source