Results 81 to 90 of about 5,069,710 (249)

Floatation of Buried Submarine Pipeline under Cyclic Loading of Water Pressure -Numerical and Experimental Studies- [PDF]

, 2000
A dynamic response of a submarine pipeline buried in sandy seabed sediments to water loading generated by harmonically oscillating water-table vertical movements is examined in the present report experimentally and numerically.
Maeno, Shiro, Magda, Waldemar, Nago, Hiroshi   +2 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A surface-charge model for mudstones and the application to Pore Pressure Prediction [PDF]

, 2005
New geologic concepts have been developed that illuminate the critical role of bound water in the generation and prediction of overpressures in mudstones.
Traugott, Martin Olson
core  

Task force VI: Self-monitoring of the blood pressure.

, 1999
BACKGROUND: Self-monitoring of the blood pressure by patients at home or in other nonclinical settings has become increasingly common in recent years. This phenomenon has been fueled in part by the increase in availability of automatic sphygmomanometers,
Asmar, R., Thijs, L., Waeber, B., Mansoor, G.A., Padfield, P., Imai, Y., White, W.B.   +6 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Distribution Laws of Pore Water Pressure at the Bottom Slab of Xiamen Metro Station Structures

Chengshi guidao jiaotong yanjiu
ObjectiveThe anti-floating stability of metro station structures is one of the key technical issues in the construction of urban rail transit. Therefore, it is necessary to study the distribution characteristics of pore water pressure at the bottom slab ...
Le PENG, Honglin LIN, Zebin XIAO, Xiong WANG, Zijian LIU, Qiyun WANG, Wanjun ZANG   +6 more
doaj   +1 more source

Hydro-mechanical characterisation and monitoring through conventional and satellite data: The Calita landslide case (Italy) [PDF]

E3S Web of Conferences
Landslides involving fine-grained soils, such as earth slides and earthflows, are highly sensitive to pore water pressure variations, which can reduce soil shear strength through undrained-drained mechanisms.
Fraccica Alessandro, Maggi Matteo, D’Angiò Danilo, Bonasera Mauro, Di Paola Gianluigi, Chiessi Vittorio, Monti Gennaro Maria, Bertolini Giovanni   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Influential Factors of Loess Liquefaction and Pore Pressure Development

, 2005
The liquefaction of loess under dynamic loading is studied experimentally with a dynamic triaxial test system. The effects of over-consolidation ratio (OCR), saturation degree and the frequency of dynamic loading upon loess liquefaction are investigated.
Zhang Y, 高福平, Zhao CG, Yang ZM, Zhao, CG (reprint author), Beijing Jiaotong Univ, Sch Civil Engn, Beijing 100044, Peoples R China.   +4 more
core   +1 more source