Results 111 to 120 of about 250,229 (301)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Pore-size-distribution of cationic polyacrylamide hydrogels. Progress report [PDF]

open access: yes, 1992
The pore size distribution of a AAm/MAPTAC (acrylamide copolymerized with (3-methacrylamidopropyl)trimethylammonium chloride) hydrogel was investigated using Kuga`s mixed-solute-exclusion method, taking into account the wall effect.
Prausnitz, J. M., Kremer, M.
core   +1 more source

Study on Analytical Method for Pore Size Distribution of the Lower Cambrian Niutitang Formation Shale in Southeastern Chongqing

open access: yesYankuang ceshi, 2018
BACKGROUND The low-temperature nitrogen (N2) adsorption-desorption method has been widely used to evaluate the pore structure of shale, however, the different analytical conditions such as degassing temperature and degassing time were reported in the ...
MA Zhen-qian   +2 more
doaj   +1 more source

Correction to "Structure and Pore Size Distribution in Nanoporous Carbon". [PDF]

open access: yesChem Mater, 2022
Wang Y   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Pore size distribution in tablets measured with a morphological sieve [PDF]

open access: yes, 2007
Porosity and pore structure are important characteristics of tablets, since they influence mechanical strength and many other proper-ties. This paper proposes an alternative method for the characterization of pore structure based on image analysis of SEM
Frijlink, Henderik W.; id_orcid   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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