Results 41 to 50 of about 244,951 (247)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Porous silicon nanowires [PDF]

Nanoscale, 2011
In this mini-review, we summarize recent progress in the synthesis, properties and applications of a new type of one-dimensional nanostructures-single crystalline porous silicon nanowires. The growth of porous silicon nanowires starting from both p- and n-type Si wafers with a variety of dopant concentrations can be achieved through either one-step or ...
Yongquan, Qu, Hailong, Zhou, Xiangfeng, Duan   +2 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Synthesis and characterisation of zeolite-A and Zn-exchanged zeolite-A based on natural aluminosilicates and their potential applications

Cogent Engineering, 2018
Zeolites have been hydrothermally synthesized using alumina and silica based deposits (kaolin, bauxite, silica and feldspar) sampled from three regions in Ghana and the chemical compositions of the zeolites varied by batch formulations.
Emmanuel Nyankson, Johnson Kwame Efavi, Abu Yaya, Gloria Manu, Kingsford Asare, Joseph Daafuor, Richard Yeboah Abrokwah   +6 more
doaj   +1 more source

Investigating of size-dependent buckling and instability caused by support forces and electrostatic field in porous annular microplates [PDF]

مهندسی مکانیک شریف
In this paper, the static behavior, instability and buckling in porous micro plates under electrostatic field are investigated based on the modified couple stress theory and with regard to modeling, determining equations and solution methods.
Mahdi Mojahedi, M.R Ayatollahi, M. Mojahedi   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PVA assisted ZnO based mesoporous ternary metal oxides nanomaterials: synthesis, optimization, and evaluation of antibacterial activity

Materials Research Express, 2020
The poly (vinyl alcohol) (PVA) assisted highly mesoporous Zn-Fe-Mn oxides nanomaterials were synthesized using the sol-gel followed by the self-propagation techniques.
Buzuayehu Abebe, H C Ananda Murthy, Enyew Zerefa, Yeshaneh Adimasu   +3 more
doaj   +1 more source

Numerically Detection Fluid Characteristic Effects in Porous Media for Plastic Manufacturing Process Reconstruction

International Journal of Mathematical, Engineering and Management Sciences, 2022
Research work aimed to prove the cooling effectiveness and efficiency of heating numerically. It was carried out by reconstructing the mold to reduce condensation while keeping the production cycle time.
Muttaqin Rahmat Pangaribawa , Sunardi Wiyono , Sarjito, Niko Aji Sutopo, Fiki Amirul Khusaini   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications

Journal of Functional Biomaterials, 2022
A fine control over different dimensional scales is a challenging target for material science since it could grant control over many properties of the final material.
Devis Montroni, Takeru Kobayashi, Taige Hao, Derek Lublin, Tomoko Yoshino, David Kisailus   +5 more
doaj   +1 more source