Results 41 to 50 of about 7,354,629 (287)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
A nanostructured porous silicon based drug delivery device
, 2009 Targeted and controlled delivery of therapeutic agents on demand is pivotal in realising the efficacy of many pharmaceuticals. The design and fabrication of a novel, electrically-addressable, porous structure-based drug delivery device for the controlled
Chau, Chien Fat
core +1 more source
Possibilities of porous-structure representation – an overview
Acta Technica Jaurinensis, 2021 Porous media can be found in all areas of scientific life, such as medicine, civil engineering, material science, fluid dynamics. Computing has achieved high efficiency and computational capacity – so far. However, three-dimensional Computational Fluid Dynamics (CFD) simulations of microstructure remain significant challenges.
Herman Szűcs, Balázs Vehovszky
openaire +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The effect of surface structure on the sound absorption properties of porous glass
Xi'an Gongcheng Daxue xuebao, 2021 In order to study the influence of the surface structure of full-bore porous glass on its sound absorption properties, the surface was punched twice, the influence of surface structure parameters on the sound absorption properties of full-bore porous ...
Xubo ZHANG +5 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Mechanical performance analysis of functionally graded triply periodic minimal surfaces
AIP AdvancesTo address the issue of a single gradient direction in the gradient design of triply periodic minimal surfaces, two functional gradient schemes, trapezoidal and W-shaped, were proposed based on the stress distribution range of the uniform thickness ...
Yaochen Shi +4 more
doaj +1 more source
POROUS STRUCTURE OF ROAD CONCRETE
Наука и техника, 2016 Having a great number of concrete structure classifications it is recommended to specify the following three principal types: microstructure – cement stone structure; mesostructure – structure of cement-sand mortar in concrete; macrostucture – two ...
M. K. Pshembaev +4 more
doaj +1 more source