Results 41 to 50 of about 5,001 (177)

Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer

VIEW, EarlyView.
Illustration of the synthesis of 5‐aminolevulinic acid loaded chitosan‐sericin polyelectrolyte nanoparticles (CSSN/ALA NPs) using the Flash nanocomplexation (FNC) technique and their potential in photodynamic therapy (PDT) against breast cancer (BC). Abstract Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and ...
Athira Narayanan, Benedetta di Chiara Stanca, Daniela Pinheiro, Laura Giannotti, Fabrizio Damiano, André Ferreira Moreira, Sónia Miguel, Leonardo Lamanna, Eleonora Stanca, Maria Grazia Raucci, Gianpiero Colangelo, Luisa Siculella, Alessandro Sannino, Paula Coutinho, Christian Demitri   +14 more
wiley   +1 more source

Root Structural and Metabolic Plasticity Confers Tolerance to Salinity in Wild Barley Species Grown Under Waterlogging

Plant, Cell &Environment, Volume 49, Issue 8, Page 5593-5606, August 2026.
ABSTRACT Salinity combined with waterlogging is a major abiotic stress that severely limits crop growth and yield. We investigated species‐specific adaptations to salinity under constant waterlogging conditions in the wild halophytic barleys Hordeum marinum and H. glaucum, compared with the cultivated H. vulgare.
Stanislav Isayenkov, Ljudmilla Borisjuk, Simon Mayer, Alexander Hilo, Dominic Knoch, Tobias Meitzel, Bettina Hause, Yudelsy Antonia Tandron Moya, Hardy Rolletschek, Edgar Peiter, Volodymyr Radchuk   +10 more
wiley   +1 more source

Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum

JIMD Reports, 2023
A 47‐year‐old woman with acute intermittent porphyria (AIP) has had recurring symptoms after achieving biochemical normalization of her urinary 5‐aminolevulinic acid (ALA), porphobilinogen (PBG), and total porphyrins with givosiran.
Christopher D. Ma, Denise Faust, Herbert L. Bonkovsky   +2 more
doaj   +1 more source

Case Report: Variegate porphyria disclosed by post-gastric bypass complications and causing predominant painful sensorimotor axonal peripheral neuropathy

Frontiers in Genetics, 2022
Background and aims: Porphyrias constitute a group of rare genetic diseases due to various, mostly autosomal dominant mutations, causing enzymatic deficiency in heme biosynthesis.
Edwige Collaud, Luis Wittwer, Luis Wittwer, Anna-Elisabeth Minder, Jean-Marie Annoni, Elisabeth I. Minder, Joelle N. Chabwine, Joelle N. Chabwine   +7 more
doaj   +1 more source

Biochemical and hematological analysis in acute intermittent porphyria (AIP): a case report

Anais da Academia Brasileira de Ciências, 2013
Acute intermittent porphyria is the most common acute porphyria caused by a decrease in hepatic porphobilinogen deaminase activity, resulting in an accumulation of delta-aminolevulinic acid and porphobilinogen.
ANNA R.R. DOS SANTOS, RAFAELA R. DE ALBUQUERQUE, MARIA J.R. DORIQUI, GRACIOMAR C. COSTA, ANA PAULA S.A. DOS SANTOS   +4 more
doaj   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

Strain‐Specific Biotransformation of Grape Marc by Lactic Acid Bacteria: Genomic Validation and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Grape marc (GM) is a polyphenol‐rich winery byproduct that remains underutilized due to its complex fiber matrix, which limits the bioaccessibility of bound phenolics. While lactic acid fermentation (LAF) can enhance the release of these compounds, the strain‐specific metabolic fate of GM phenolics during digestion and colonic fermentation ...
Ziyao Liu, Hanjing Wu, Brendan Holland, Colin J. Barrow, Hafiz A. R. Suleria   +4 more
wiley   +1 more source

Porphobilinogen Synthase: A Challenge for the Chemist?

CHIMIA, 2001
The initial steps in the biosynthesis of the tetrapyrrolic dyes, called the 'pigments of life', are highly convergent. The formation of porphobilinogen, the pyrrolic precursor of the tetrapyrrolic skeleton, uses ?-aminolevulinate as the starting
Frédéric Stauffer, Eleonora Zizzari, Carole Soldermann-Pissot, Jean-Philippe Faurite, Reinhard Neier   +4 more
doaj  

A Commonly Missed Well Known Entity- Acute Intermittent Porphyria: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Acute Intermittent Porphyria (AIP) usually presents with abdominal pain, peripheral neuropathy and psychiatric manifestations. Incidence of AIP being 5 in 1,00,000.
Smilu Mohanlal, Radha Gulati Ghildiyal, Alpana Kondekar, Poonam Wade, Richa Sinha   +4 more
doaj   +1 more source

Isolation and Characterization of SPOTTED LEAF42 Encoding a Porphobilinogen Deaminase in Rice

Plants, 2023
The formation and development of chloroplasts play a vital role in the breeding of high-yield rice (Oryza sativa L.). Porphobilinogen deaminases (PBGDs) act in the early stage of chlorophyll and heme biosynthesis.
Lin Liu, Yunpeng Wang, Yunlu Tian, Shuang Song, Zewan Wu, Xin Ding, Hai Zheng, Yunshuai Huang, Shijia Liu, Xiaoou Dong, Jianmin Wan, Linglong Liu   +11 more
doaj   +1 more source