Results 61 to 70 of about 4,692 (177)

Acute Intermittent Porphyria in Childhood Presenting with Hypertensive Emergency and Posterior Reversible Encephalopathy Syndrome

Journal of Pediatric Critical Care, 2016
Acute intermittent porphyria is an inherited metabolic disease due to deficiency of the enzyme porphobilinogen deaminase that can affect the autonomic, peripheral and central nervous system.
Rishab Bharadwaj, Pallavi P Dagli, Aasheeta S Shah   +2 more
doaj   +1 more source

Nanosensors in Leukemia Management: Pioneering Real‐Time Biomarker Detection for Precision Oncology

Nano Select, Volume 6, Issue 12, December 2025.
This review highlights pioneering nanosensors designed for real‐time leukemia biomarker detection, integrating advanced nanomaterials such as liposomes, polymeric nanoparticles and quantum dots. It examines electrochemical, optical and magnetic detection mechanisms, the applications across AML, ALL, CML, and CLL subtypes, and clinical translation ...
Hamed Soleimani Samarkhazan, Mohammad Navid Khaksari, Amirhossein Mirzazadeh, Mohammad Siavashi, Niloofar Pilehvari, Mohammad Hossein Mohammadi   +5 more
wiley   +1 more source

Beyond Methane Oxidation: The Protein Landscape of ANME‐2a Reveals an Integrated System for Diazotrophy and Membrane Fortification

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
A protein interaction network of ANME‐2a uncovers a modular blueprint where core methane oxidation is energetically coupled to nitrogen fixation and membrane lipid biosynthesis. This integrated system explains the archaeon's metabolic autonomy and resilience in its extreme deep‐sea niche.
Samuel de Souza e Silva, Natanael Borges de Avila, Alisson William da Silva, Lucas Ramos Fernandes da Silva, Matheus Ribeiro Prado, Murilo Alves Beppler, Anderson Rodrigues dos Santos   +6 more
wiley   +1 more source

Microglial SLC25A28 Knockout Mitigates Spinal Cord Injury in Mice by Inhibiting Heme Synthesis and Subsequent NOX2 Activation

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Microglial SLC25A28 knockout reduces spinal cord injury by inhibiting mitochondrial iron accumulation and heme synthesis, leading to decreased NOX2 activation and neuroinflammation. This study reveals the SLC25A28‐heme‐NOX2 axis as a key regulator of microglial‐driven secondary damage after SCI.
Huangtao Chen, Shaochun Guo, Yanglan Mi, Ruili Han, Yuxin Xi, Tingwei Peng, Longhui Fu, Weidong Liu, Ruiyu Ma, Beibei Yu, Yongfeng Zhang, Luyao Li, Jing Ye, Shouping Gong   +13 more
wiley   +1 more source

Studies on porphobilinogen [PDF]

Biochemical Journal, 1953
P E, BROCKMAN, C H, GRAY
openaire   +2 more sources

Porphyric encephalopathy in a 15-year-old girl: A case report

SAGE Open Medical Case Reports
A 15-year-old girl presented with new onset tonic-clonic seizures, encephalopathy, abdominal pain, and hypertension with a history of weight loss and emesis.
Saihari S Dukkipati, Jordan Terschluse, Drew Thodeson, Angela Beavers, Melissa Muff-Luett, Claire Ives, Sookyong Koh   +6 more
doaj   +1 more source

Acute Intermittent Porphyria: A Report of 3 Cases with Neuropathy

Case Reports in Neurology, 2019
The porphyrias are metabolic disorders due to a defect in the heme biosynthetic pathway. Patients have diverse clinical presentations with neuropathy being frequent in acute intermittent porphyria (AIP).
Mohammed Alqwaifly, Vera Bril, Dubravka Dodig   +2 more
doaj   +1 more source

Hepatocyte Transplantation Ameliorates the Metabolic Abnormality in a Mouse Model of Acute Intermittent Porphyria

Cell Transplantation, 2014
Acute intermittent porphyria (AIP) is an autosomal dominant disorder characterized by insufficient porphobilinogen deaminase (PBGD) activity. When hepatic heme synthesis is induced, porphobilinogen (PBG) and 5-aminolevulinic acid (ALA) accumulate, which ...
Zhaohui Yin, Staffan Wahlin M.D., Ph.D., Ewa C. S. Ellis, Pauline Harper, Bo-Göran Ericzon, Greg Nowak   +5 more
doaj   +1 more source

Rat Porphobilinogen Deaminase Gene: A Pseudogene-Free Internal Standard for Laser-Assisted Cell Picking

BioTechniques, 1999
Analysis of gene expression and its transcriptional regulation requires a reliable access to target mRNA. However, mRNA extractions from homogenized tissue are limited because only average data are obtained, and cell-specific expression may not be ...
L. Fink, U. Stahl, L. Ermert, W. Kummer, W. Seeger, R.M. Bohle   +5 more
doaj   +1 more source

A Quantitative Assay for Urinary Porphobilinogen

Clinical Chemistry, 1964
Abstract A procedure has been developed for the rapid, quantitative determination of urinary porphobilinogen. Interfering substances are removed by selectively adsorbing the porphobilinogen with an ion-exchange resin using a batch method.
D J, MOORE, R F, LABBE
openaire   +2 more sources