Results 61 to 70 of about 8,773 (221)

Porphobilinogen Synthase: A Challenge for the Chemist?

CHIMIA, 2001
The initial steps in the biosynthesis of the tetrapyrrolic dyes, called the 'pigments of life', are highly convergent. The formation of porphobilinogen, the pyrrolic precursor of the tetrapyrrolic skeleton, uses ?-aminolevulinate as the starting
Frédéric Stauffer, Eleonora Zizzari, Carole Soldermann-Pissot, Jean-Philippe Faurite, Reinhard Neier   +4 more
doaj  

Physiological and transcriptomic evidence for a close coupling between chloroplast ontogeny and cell cycle progression in the pennate diatom Seminavis robusta [PDF]

, 2008
Despite the growing interest in diatom genomics, detailed time series of gene expression in relation to key cellular processes are still lacking. Here, we investigated the relationships between the cell cycle and chloroplast development in the pennate ...
Chepurnov, Victor A, D'hondt, Sofie, De Veylder, Lieven, Devos, Valerie, Gillard, Jeroen, Huysman, Marie, Inzé, Dirk, Martens, Cindy, Sabbe, Koen, Vannerum, Katrijn, Vanormelingen, Pieter, Vuylsteke, Marnik, Vyverman, Wim   +12 more
core   +3 more sources

Psychiatric Symptoms in Acute Intermittent Porphyria - Case Report and Course of Treatment Using Placebo

Journal of Education, Health and Sport
Introduction: Acute intermittent porphyria is a disease inherited in an autosomal dominant manner, occurring with a frequency of 1:75,000 people.
Waldemar Kosiba, Dominika Prystacka-Szar, Jakub Siemko, Wojciech Kupczak   +3 more
doaj   +1 more source

Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules

Journal of Molecular Recognition, Volume 39, Issue 1, January 2026.
ABSTRACT Sirtuin 6 (SIRT6) is an enzyme belonging to the class of nicotinamide adenine dinucleotide (NAD+) dependent histone deacetylases. It has been of interest due to its multivariate biological role and association with aging‐related diseases and metabolic dysfunctions.
Érika Geicianny de Carvalho Matias, Katyanna Sales Bezerra, Washington Sales Clemente Junior, Jonas Ivan Nobre Oliveira, Douglas Soares Galvão, Umberto Laino Fulco   +5 more
wiley   +1 more source

Structural insights into E. coli porphobilinogen deaminase during synthesis and exit of 1-hydroxymethylbilane.

PLoS Computational Biology, 2014
Porphobilinogen deaminase (PBGD) catalyzes the formation of 1-hydroxymethylbilane (HMB), a crucial intermediate in tetrapyrrole biosynthesis, through a step-wise polymerization of four molecules of porphobilinogen (PBG), using a unique dipyrromethane ...
Navneet Bung, Meenakshi Pradhan, Harini Srinivasan, Gopalakrishnan Bulusu   +3 more
doaj   +1 more source

Implanted Progestin Causing Pain and Psychiatric Disturbances in Porphyria Attack: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2023
Introduction: Acute hepatic porphyrias (AHP) are a rare group of inherited disorders caused by abnormal functioning of the heme synthesis pathway. Patients often present with diffuse abdominal pain, neurologic dysfunction, and hyponatremia.
Ryan K. Misek, Massimo F. Riitano
doaj   +1 more source

Acute intermittent porphyria: a test of clinical acumen

Journal of Community Hospital Internal Medicine Perspectives, 2017
Acute intermittent porphyria (AIP) is a rare autosomal dominant hepatic porphyria due to deficiency of hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase leading to accumulation of porphyrin precursors.
Rashmi Dhital, Sijan Basnet, Dilli Ram Poudel, Khema Raj Bhusal   +3 more
doaj   +1 more source

In Vitro Optimization of Enzymes Involved in Precorrin-2 Synthesis Using Response Surface Methodology.

PLoS ONE, 2016
In order to maximize the production of biologically-derived chemicals, kinetic analyses are first necessary for predicting the role of enzyme components and coordinating enzymes in the same reaction system. Precorrin-2 is a key precursor of cobalamin and
Huan Fang, Huina Dong, Tao Cai, Ping Zheng, Haixing Li, Dawei Zhang, Jibin Sun   +6 more
doaj   +1 more source

Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Bacillus megaterium enzyme at near-atomic resolution. [PDF]

, 2014
The enzyme porphobilinogen deaminase (PBGD; hydroxymethylbilane synthase; EC 2.5.1.61) catalyses an early step of the tetrapyrrole-biosynthesis pathway in which four molecules of the monopyrrole porphobilinogen are condensed to form a linear tetrapyrrole.
Akhtar, M, Azim, N, Coker, A, Cooper, JB, Deery, E, Erskine, P, Warren, MJ, Wolfenden, BA, Wood, SP   +8 more
core   +1 more source

Quantitative Analyses of Programmed Cell Death (PCD) Relevant Indicators in Postharvest Vegetable

Future Postharvest and Food, Volume 2, Issue 4, Page 444-457, December 2025.
The PCD relevant indicators of postharvest vegetable. ABSTRACT The measurement of factors related to postharvest programmed cell death (PCD) in vegetables is crucial for understanding the physiological and metabolic pathways involved in vegetable ripening, aging, and stress responses. PCD is an actively regulated process orchestrated by the interaction
Qianqian Shi, Jiahui Chen, Shifeng Cao, Yingying Wei, Xingfeng Shao, Feng Xu   +5 more
wiley   +1 more source