Results 11 to 20 of about 63,566 (303)
Interlocked Porphyrin Switches [PDF]
Chemistry – A European Journal, 2013 AbstractWe describe the synthesis of a series of interlocked structures from porphyrin–glycoluril cage compounds and bis(olefin)‐terminated viologens by an olefin‐metathesis protocol. The length of the chain connecting the olefin substituents with the viologen has a marked effect on the products of the ring‐closure reaction.
Coumans, R.G.E. +5 more
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Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]
, 2014 The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W. +6 more
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Thiol regulation by Mn porphyrins, commonly known as SOD mimics
Redox Biology, 2019 Superoxide dismutases play an important role in human health and disease. Three decades of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn porphyrins which have SOD-like activity.
Ines Batinic-Haberle, Margaret E. Tome
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Assessing the In Vitro Activity of Selected Porphyrins in Human Colorectal Cancer Cells
Molecules, 2022 Standard in vitro analyses determining the activity of different compounds included in the chemotherapy of colon cancer are currently insufficient. New ideas, such as photodynamic therapy (PDT), may bring tangible benefits.
Maciej Piotr Frant +2 more
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Peripherally-metallated porphyrins: meso-n1-porphyrinyl-platinum(II) complexes of 5,15-diaryl- and 5,10,15-triarylporphyrins [PDF]
, 2002 Attempted metathesis reactions of peripherally-metallated meso-η1-porphyrinylplatinum(II) complexes such as trans-[PtBr(NiDPP)(PPh3)2] (H2DPP = 5,15-diphenylporphyrin) with organolithium reagents fail due to competitive addition at the porphyrin ring ...
Arnold, Dennis +2 more
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Metalloporphyrins inactivate caspase-3 and -8 [PDF]
, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
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Porphyrinic metal-organic frameworks for biological applications
Advanced Sensor and Energy Materials, 2023 Porphyrins and their derivatives have been extensively applied in various fields owing to their photophysical and electrochemical properties. However, the drawbacks of self-aggregation and self-quenching in aqueous media limit their biological ...
Li-Jian Chen, Xu Zhao, Xiu-Ping Yan
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Immobilized photosensitizers for antimicrobial applications [PDF]
, 2015 Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms; this is due to the fact that it is virtually impossible for resistant strains to ...
Boyle, Ross W. +2 more
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The photodynamic and non-photodynamic actions of porphyrins
Brazilian Journal of Medical and Biological Research, 1999 Porphyrias are a family of inherited diseases, each associated with a partial defect in one of the enzymes of the heme biosynthetic pathway. In six of the eight porphyrias described, the main clinical manifestation is skin photosensitivity brought about ...
S.G. Afonso +2 more
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Aggregate, 2023 Porphyrins are among the most important macrocycles because they perform many essential functions in living systems and serve as building blocks in many functional materials. Incorporating the chirality into porphyrins can aid biomimetic research and the
Li Zhang +3 more
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