Results 141 to 150 of about 726,100 (301)

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Regional Hub Port Development - The Case of Montevideo, Uruguay [PDF]

This paper reflects on port development in Uruguay in an environment of trilateral interport competition. The regional characteristics of port development in terms of their geographical, functional and operational characteristics are discussed by ...
Gordon Wilmsmeier, Inmaculada Martínez-Zarzoso, Norbert Fiess   +2 more
core  

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Allocating Quay in Optimal Layout Design for Mixed Queuing Systems in Marine Vessels Using a Quadratic Programming Formulation

Applications of Modelling and Simulation
In this paper, we use the dataset of a marine berthing structure per hour to construct the objective and linear constraint functions from the combination of a simple and non-preemptive queuing model, and we determine the optimal design of vessels and ...
Koumbe Mbock, Okpwe Mbarga Richard, Lezin Seba Minsili, Etoua Remy Magloire   +3 more
doaj  

Conversion of a ventricular rickham reservoir to a subcutaneous chest port for repeated intraventricular enzyme replacement therapy: technical note and surgical considerations. [PDF]

Childs Nerv Syst
Gopalka M, Manocha S, Romanski K, Hoeman E, Boop S, Lam SK.   +5 more
europepmc   +1 more source

A Rigid–Foldable Kirigami‐Inspired Metamorphic Mechanism With Programmable Motion Modes and Self‐Locking

Advanced Science, EarlyView.
Geometric constraint reconfiguration enables a rigid–foldable kirigami‐inspired mechanism to switch between twisting, directional translation, and self‐locking states. By encoding multifunctionality directly into its architecture, the mechanism achieves multimodal motion and passive locking without reassembly, providing a compact platform for adaptive ...
Jianlin Wang, Zhongmin Song, Ketao Zhang
wiley   +1 more source

Mechanisms Underlying an Enhanced Navigation-Based Intervention to Improve Timely Adjuvant Therapy: A Secondary Analysis of the NDURE Randomized Clinical Trial. [PDF]

JAMA Otolaryngol Head Neck Surg
Elhage MN, Kistner-Griffin E, DeMass R, Chera BS, Sterba KR, Halbert CH, Hill EG, Nussenbaum B, Alberg AJ, Nguyen MT, Newman JG, Albergotti WG, Kejner AE, Skoner JM, Adilbay D, Bobian M, Harper JL, Kaczmar J, Zimmerman SA, Stewart S, McLeod T, Sandulache VC, Hermandez DJ, Jackson RS, Puram SV, Kahmke R, Osazuwa-Peters N, Jackson G, Wasp GT, Yom SS, Graboyes EM.   +30 more
europepmc   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

« Ports gabonais et enjeux logistiques – Compte rendu de la thèse de Gisèle Makiela-Magambou »

Netcom, 2007
Henry Bakis
doaj   +1 more source

Laparoscopic cholecystectomy in situs inversus totalis. [PDF]

BMJ Case Rep
Keys M, Colbran R, Hodgkinson P.
europepmc   +1 more source