Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
Journal of Raman Spectroscopy, EarlyView.An interdisciplinary in situ study of jewelled reliquaries of the True Cross integrates gemmology and portable analytical techniques, revealing new evidence on the identification and symbolic role of peridots and other gemstones. ABSTRACT Jewelled crosses containing relics of the True Cross occupy a central position in the devotional, artistic and ...
Stefania Martiniello +2 more
wiley +1 more source
Journal of Raman Spectroscopy, EarlyView.This study addresses calibration drift in Raman spectroscopy by transforming 1D spectra into 2D spider plot images processed by pretrained convolutional neural networks. This visualization strategy effectively converts detrimental spectral wavenumber shifts into simple image rotations, allowing the deep learning model to maintain high classification ...
Azadeh Mokari +2 more
wiley +1 more source
Quick Analysis of Organic Amendments via Portable X-ray Fluorescence Spectrometry. [PDF]
Int J Environ Res Public Health, 2019 López-Núñez R +4 more
europepmc +1 more source
Analysis of Corrosion and Wall Perforation in the Heat Exchanger Made of AISI 316L Stainless Steel
Materials and Corrosion, EarlyView.Elevated passivation temperature is identified as the dominant factor triggering localized corrosion and subsequent perforation of AISI 316L heat exchanger tubes. Electrochemical and complementary characterization results show that the alloy retains high resistance to general, pitting, and intergranular corrosion, indicating that failure primarily ...
Bojana Radojković +7 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg +2 more
wiley +1 more source
Geophysical Monograph Series, Page 329-339., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Vladimir Kutcherov +3 more
wiley +1 more source
Development and optimisation of ex situ portable X-ray fluorescence spectroscopy for heterogenous post-metallurgical sites. [PDF]
Environ Geochem HealthMarsay NH +3 more
europepmc +1 more source
Responsive Materials, EarlyView.Machine learning provides a unifying framework to connect structure, fluorescence properties, and applications of carbon‐based quantum dots. This review highlights how data‐driven strategies enable fluorescence regulation, reveal underlying mechanisms, and accelerate the rational design of functional carbon dots.
Liangfeng Chen +8 more
wiley +1 more source
Portable X-ray fluorescence of zinc and selenium with nail clippings-Mother and Infant Nutrition Investigation (MINI). [PDF]
PLoS OneFleming DEB +8 more
europepmc +1 more source