Results 101 to 110 of about 5,466,189 (313)

Ateşe Arz, Hark-İltiâm ve Portal Kavramlarından Hareketle Kabir Azabının Keyfiyetine Dair Muhtemel Senaryolar

Kader
İslâm dininin itikadî hükümlerinin ispâtında kullanılan aklî ve naklî deliller kadar önemli hususlardan birisi, itikadî hükümlerin muhatabın idrak ve akıl seviyesine uygun bir din dili kullanılarak izah edilmesidir.
Vezir Harman
doaj   +1 more source

" The interest of studying Pokémons is to demonstrate that, sometimes, the children are extraordinary competents to learn.”

Zero-a-seis, 2006
nterview granted to Journalist Vitor Casimiro, of the Portal he/she Learns Brazil, with the French educator Gilles Brougére, specialist in games and infantile games.
Vitor Casimiro
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Ferramentas Web 2.0 para atividades em Educação a Distância utilizadas em conjunto com o ambiente virtual de aprendizagem Moodle

EaD & Tecnologias Digitais na Educação, 2014
Este artigo visa a buscar ferramentas Web 2.0 com a proposta de utilizá-las em atividades em cursos de Educação a Distância (EaD) na modalidade online que adotam o Ambiente Virtual de Aprendizagem (AVA) Moodle, já que essas ferramentas estão populares e ...
Viviane Naomi Kay
doaj  

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Barómetro Sanitario: principales resultados. Datos de 2008

, 2009
Datos estadísticos elaborados por Portal Mayores, sobre el sistema sanitario público español y la valoración del mismo por la población, a fecha de 2008Desarrollo y crecimiento de un sistema de información sobre personas mayores en la Red.
Equipo Portal Mayores
core  

Portal corporativo como canal para gestão do conhecimento [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia e Gestão do ConhecimentoA Era da Informação traz um novo contexto ao mundo empresarial, no qual o conhecimento passa a ser visto ...
Uriarte, Flavia Maia da Nova
core  

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Estadísticas sobre residencias: distribución de centros y plazas residenciales

, 2005
Estadísticas procedentes de la base de datos de Residencias en 2004, elaboradas por Portal ...
Equipo Portal Mayores
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source