Results 101 to 110 of about 2,349,257 (305)

Tunnel Portal Construction using Sequential Excavation Method: A Case Study

MATEC Web of Conferences, 2017
Portal excavation in soft rock is one of the most challenging tasks in the construction of underground facilities. Significant convergence, collapses and surface settlement are usually associated with portal construction. Alluvium is loose unconsolidated
Khan Rana Muhammad Asad, Emad Zaka, Jo ByungWan   +2 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Study of the course of inferior epigastric artery with reference to laparoscopic portal

Journal of Minimal Access Surgery, 2013
Introduction: Laparoscopy has been in vogue for more than 2 decades. Making portals in the anterior abdominal wall for introducing laparoscopic instruments is done with trocar and cannula which is a blind procedure.
Manvikar Purushottam Rao, Vatsala Swamy, Vasanti Arole, Paramatma Mishra   +3 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Ruta de escape

Poligramas, 2018
Odio mi vida, quiero largarme. La motocicleta truena a la una de la mañana por cuarta vez esta semana. Despierto sobresaltado, con la sensación de que en ella va el ladrón de algo muy valioso para mí.
Giussepe Ramírez
doaj   +1 more source

The Double-Dark Portal

, 2014
In most models of the dark sector, dark matter is charged under some new symmetry to make it stable. We explore the possibility that not just dark matter, but also the force carrier connecting it to the visible sector is charged under this symmetry. This
Curtin, David, Tsai, Yuhsin
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Ateşe Arz, Hark-İltiâm ve Portal Kavramlarından Hareketle Kabir Azabının Keyfiyetine Dair Muhtemel Senaryolar

Kader
İslâm dininin itikadî hükümlerinin ispâtında kullanılan aklî ve naklî deliller kadar önemli hususlardan birisi, itikadî hükümlerin muhatabın idrak ve akıl seviyesine uygun bir din dili kullanılarak izah edilmesidir.
Vezir Harman
doaj   +1 more source

" The interest of studying Pokémons is to demonstrate that, sometimes, the children are extraordinary competents to learn.”

Zero-a-seis, 2006
nterview granted to Journalist Vitor Casimiro, of the Portal he/she Learns Brazil, with the French educator Gilles Brougére, specialist in games and infantile games.
Vitor Casimiro
doaj   +1 more source