Results 121 to 130 of about 2,349,257 (305)
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
TIPS and HCC: friends or foes ? [PDF]
, 2016 Portal hypertension and hepatocellular carcinoma [HCC] are major complications of liver cirrhosis and may coexist in the same patient. Transjugular intrahepatic portosystemic shunt [TIPS] is an effective treatment for recurrent variceal bleeding
DE SANTIS, Adriano
core
Advanced Science, EarlyView.This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu +18 more
wiley +1 more source
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
K problematike stredovekého portálu kláštorného kostola v Šahách
Archaeologia Historica, 2013 Príspevok sa venuje západnému portálu dnes farského, pôvodne kláštorného kostola premonštrátov v Šahách. Portál je významnou pamiatkou kameňosochárstva 13. storočia na Slovensku, bez analógií v regionálnych reláciách. Jedným z jeho formových východísk sa
Štefan Oriško
doaj
Advanced Science, EarlyView.This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim +10 more
wiley +1 more source
Advanced Science, EarlyView.This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy +16 more
wiley +1 more source
Advanced Science, EarlyView.After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang +19 more
wiley +1 more source
CONTENT MANAGEMENT SYSTEM FOR EDUСATIONAL SITES
Інформаційні технології і засоби навчання, 2010 Technological aspects of Content Management System (CMS-system), developed by the Internet-center of education branch are analysed in the article. As well as CMS-system for site "PCERU" (Public Council of Education and Researchers of Ukraine), portal of ...
Natalia T. Zadorozhna +2 more
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