Results 71 to 80 of about 2,349,257 (305)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Probing the fermionic Higgs portal at lepton colliders [PDF]

open access: yes, 2016
We study the sensitivity of future electron-positron colliders to UV completions of the fermionic Higgs portal operator $H^\dagger H \bar \chi \chi$. Measurements of precision electroweak $S$ and $T$ parameters and the $e^+e^- \to Zh$ cross section at ...
Fedderke, Michael A.   +2 more
core   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

First-principles study of the atomic and electronic structure of the Si(111)-(5x2-Au surface reconstruction

open access: yes, 2005
We present a systematic study of the atomic and electronic structure of the Si(111)-(5x2)-Au reconstruction using first-principles electronic structure calculations based on the density functional theory.
A. Kirakosian   +12 more
core   +1 more source

The incidence of portal vein thrombosis at liver transplantation [PDF]

open access: yes, 1992
The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades.
Iwatsuki, S   +3 more
core   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein   +13 more
wiley   +1 more source

Lessons From the Pacific Ocean Portal: Building Pacific Island Capacity to Interpret, Apply, and Communicate Ocean Information

open access: yesFrontiers in Marine Science, 2019
The need for improved access to ocean observations for Pacific Island countries (PICs) and territories has been increasingly recognized over the last decade, particularly in the face of a changing climate.
Molly Powers   +3 more
doaj   +1 more source

Magnetism of Substitutional Co Impurities in Graphene: Realization of Single $\pi$-Vacancies [PDF]

open access: yes, 2009
We report {\it ab initio} calculations of the structural, electronic and magnetic properties of a graphene monolayer substitutionally doped with Co (Co$_{sub}$) atoms.
Ayuela, A.   +2 more
core   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Ultrasonography for Noninvasive Assessment of Portal Hypertension

open access: yesGut and Liver, 2017
Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US)
Hitoshi Maruyama, Osamu Yokosuka
doaj   +1 more source

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