Results 41 to 50 of about 1,261,128 (384)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Diagnosis and Management of Esophageal and Gastric Variceal Bleeding: Focused on 2019 KASL Clinical Practice Guidelines for Liver Cirrhosis

The Korean Journal of Gastroenterology, 2022
Varices are a frequent complication of liver cirrhosis and a major cause of mortality in patients with liver cirrhosis. Patients with decompensated cirrhosis complications have a poor prognosis and require careful management.
Min Kyung Park , Yun Bin Lee
doaj   +1 more source

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients with Nonalcoholic Steatohepatitis With Cirrhosis And Portal Hypertension.

Gastroenterology, 2019
BACKGROUND & AIMS Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contributes to toxin-induced liver fibrosis in mice.
N. Chalasani, M. Abdelmalek, G. Garcia‐Tsao, R. Vuppalanchi, N. Alkhouri, M. Rinella, M. Noureddin, Maxmillan Pyko, M. Shiffman, A. Sanyal, A. Allgood, H. Shlevin, Rex Horton, E. Zomer, W. Irish, Z. Goodman, S. Harrison, P. Traber, M. Abdelmalek, L. Balart, B. Borg, M. Charlton, H. Conjeevaram, M. Fuchs, R. Ghalib, P. Gholam, D. Halegoua-De Marzio, S. Harrison, Christopher Jue, N. Kemmer, K. Kowdley, M. Lai, E. Lawitz, R. Loomba, A. Paredes, M. Rinella, D. Rockey, Miguel J. Rodríguez, R. Rubin, M. Ryan, A. Scanga, T. Sepe, B. Tetri, P. Thuluvath, D. Torres, J. Vierling, J. Wattacheril, A. Weiland, D. Zogg   +48 more
semanticscholar   +1 more source

REVERSAL OF HEPATIC ALPHA-1-ANTITRYPSIN DEPOSITION AFTER PORTACAVAL SHUNT [PDF]

, 1983
End-to-side portacaval shunts were carried out in three children with the liver disease of alpha-1-antitrypsin deficiency and complications of portal hypertension. Their clinical courses have been stable for 31/2 to almost 7 years.
Aagenaes, Bell, Bismuth, Fisher, Hercz, Hood, Jamieson, Kuhlenschmidt, Lawford, Putnam, Sharp, Sotos, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl   +17 more
core   +1 more source

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Association between splenectomy and portal hypertension in the development of pulmonary hypertension

Pulmonary Circulation, 2020
Both portal hypertension and splenectomy are risk factors for pulmonary hypertension. However, the interactions between portal hypertension and splenectomy in the development of pulmonary hypertension remain unclear.
Li Huang, Wen Li, Tao Yang, Changming Xiong, Xinhai Ni, Qing Gu, Jianguo He   +6 more
doaj   +1 more source

Imaging Approach to Portal Hypertension

Journal of Gastrointestinal and Abdominal Radiology, 2023
Increase in portal venous pressure (termed portal hypertension) is seen in a variety of liver diseases. Imaging tests are useful to detect portal hypertension and identify its cause.
Antony Augustine, Reetu John, Betty Simon, Anuradha Chandramohan, Shyamkumar N. Keshava, Anu Eapen   +5 more
doaj   +1 more source

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension.

Gastroenterology, 2019
BACKGROUND & AIMS Mechanical forces contribute to portal hypertension (PHTN) and fibrogenesis. We investigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs) into pressure and matrix changes.
M. Hilscher, Tejasav S. Sehrawat, J. Arab, Zhutian Zeng, Jinhang Gao, Mengfei Liu, Enis Kostallari, Yandong Gao, Douglas A. Simonetto, Usman Yaqoob, S. Cao, A. Revzin, A. Beyder, Rong A. Wang, P. Kamath, P. Kubes, V. Shah   +16 more
semanticscholar   +1 more source

Elevated Gastric Antrum Erosions in Portal Hypertension Patients: Peptic Disease or Mucosal Congestion?

The Korean Journal of Gastroenterology, 2017
Background/Aims: Portal hypertension (PH) is a syndrome characterized by chronic increase in the pressure gradient between the portal vein and inferior vena cava. Previous studies have suggested an increased frequency of antral elevated erosive gastritis
Fernanda Cordeiro de Azevedo Conejo, Mabel Tatty Medeiros Fracassi, Maurício Saab Assef, Maurício Alves Ribeiro, Luiz Arnaldo Szutan, Fabio Gonçalves Ferreira   +5 more
doaj   +1 more source