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Emerging Therapeutic Targets for Portal Hypertension. [PDF]
PURPOSE OF REVIEW Portal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have improved prognosis, but this is still far from ideal.
Sonia Selicean +11 more
core +2 more sources
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto +5 more
wiley +1 more source
Application of Ultrasound Elastography in Assessing Portal Hypertension
Portal hypertension is a common manifestation in late-to-end-stage liver diseases and can cause severe complications such as ascites, hepatic encephalopathy, etc.
Man Zhang +10 more
doaj +1 more source
COLOURDOPPLER AND ULTRASONOGRAPHIC EVALUATION OF PORTAL HYPERTENSION
Introduction:An accurate non-invasive method of determining the cause, degree, and problems of portal hypertension is ultrasound doppler. Using ultrasonic Doppler, the varied spectrum of results, flow metric variations, and portosystemic collaterals may ...
Rama Krishna Rao Baru +3 more
core +1 more source
TTC21B: From Modifier to Causative Gene in Joubert Syndrome
ABSTRACT Biallelic pathogenic variants in TTC21B, encoding the retrograde intraflagellar transport protein IFT139, are a known cause of renal and skeletal ciliopathies. Single heterozygous variants in this gene were found to be enriched in a cohort of patients with various ciliopathy phenotypes, including three individuals with Joubert syndrome (JS), a
Valentina Serpieri +5 more
wiley +1 more source
Features of encephalopathy diagnosis in patients with portal hypertension syndrome
Background. Hepatic encephalopathy is a pathological change in the brain functions of non-inflammatory origin, which is manifested by a syndrome of secondary neurological and cognitive disorders caused by a set of deep metabolic disorders, as a result of
Yu.M. Stepanov +2 more
doaj +1 more source
Portal‐hypertensive gastropathy
ABSTRACTIn the present article we describe updated information concerning the clinical feature of portal‐hypertensive gastropathy (PHG), which is characterized by mucosal and submucosal vascular dilatation without inflammation. Although this lesion represents non‐variceal bleeding, there is a wide variation of its prevalence.
TOYONAGA, Atsushi, IWAO, Tadashi
openaire +3 more sources
Non-invasive assessment and prediction of clinically significant portal hypertension
Hepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres.
Austin, Andrew +7 more
core +1 more source
Purpose To compare clinical outcomes and ultrasound‐assessed healing rates between posterosuperior and anterior rotator cuff repairs using propensity score matching. Methods Consecutive patients undergoing rotator cuff repair between 2015 and 2021 by a single fellowship‐trained shoulder surgeon were included if they had posterosuperior or anterior ...
Mustafa S. Rashid +6 more
wiley +1 more source
Noninvasive Evaluation of Portal Hypertension: Emerging Tools and Techniques
Portal hypertension is the main cause of complications in patients with cirrhosis. However, evaluating the development and progression of portal hypertension represents a challenge for clinicians.
V. K. Snowdon +2 more
doaj +1 more source

