Results 71 to 80 of about 89,230 (317)
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen +9 more
wiley +1 more source
CAQ Corner: Immune‐mediated complications
, 2022 Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley +1 more source
Features of encephalopathy diagnosis in patients with portal hypertension syndrome
Gastroenterologìa, 2017 Background. Hepatic encephalopathy is a pathological change in the brain functions of non-inflammatory origin, which is manifested by a syndrome of secondary neurological and cognitive disorders caused by a set of deep metabolic disorders, as a result of
Yu.M. Stepanov +2 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
Frontiers in Physiology, 2021 IntroductionMacrophages are involved in development and progression of chronic liver disease and portal hypertension. The macrophage activation markers soluble (s)CD163 and soluble mannose receptor (sMR), are associated with portal hypertension in ...
Nikolaj Worm Ørntoft +10 more
doaj +1 more source
A pathway-based network analysis of hypertension-related genes [PDF]
Physica A 447 (2016) 569--570, 2016 Complex network approach has become an effective way to describe interrelationships among large amounts of biological data, which is especially useful in finding core functions and global behavior of biological systems. Hypertension is a complex disease caused by many reasons including genetic, physiological, psychological and even social factors.
arxiv +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana +8 more
wiley +1 more source
Model Selection for Maternal Hypertensive Disorders with Symmetric Hierarchical Dirichlet Processes [PDF]
arXiv, 2022 Hypertensive disorders of pregnancy occur in about 10% of pregnant women around the world. Though there is evidence that hypertension impacts maternal cardiac functions, the relation between hypertension and cardiac dysfunctions is only partially understood.
arxiv
Clinical Pharmacology &Therapeutics, EarlyView.Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima +11 more
wiley +1 more source
Noninvasive Evaluation of Portal Hypertension: Emerging Tools and Techniques
International Journal of Hepatology, 2012 Portal hypertension is the main cause of complications in patients with cirrhosis. However, evaluating the development and progression of portal hypertension represents a challenge for clinicians.
V. K. Snowdon +2 more
doaj +1 more source