Results 71 to 80 of about 101,214 (211)

Antioxidant effect of N-acetylcysteine on prehepatic portal hypertensive gastropathy in rats

Annals of Hepatology, 2014
Background. Portal hypertension is a clinical syndrome associated with the development of a hyperdynamic circulation and gastroesophageal varices.Aim. To evaluate the antioxidant effect of N-acetylcysteine on portal hypertensive rats.Material and methods.
Francielli Licks, M.sc., Camila Marques, Cláudio Zetler, Maria I. Morgan Martins, Cláudio A. Marroni, Norma P. Marroni   +5 more
doaj   +1 more source

Longitudinal Multifrequency MR Elastography Reveals Biomechanical Signatures of Progression in a Translational Liver Tumor Model

Advanced Science, EarlyView.
Longitudinal multifrequency magnetic resonance elastography (mMRE) performed on a clinical 3 Tesla magnetic resonance imaging system reveals early biomechanical alterations during liver tumor progression in a translational VX2 model. Changes in tumor stiffness and viscosity precede diffusion‐related alterations and are associated with extracellular ...
Justus Ramtke, Friederike Hesse, Lasse Noack, Justus Klockner, Yubei He, Yu Liu, Yanglei Wu, Robin Schmidt, Selma Saclier, Salma A. S. Abosabie, Tom Meyer, Richard Ruppel, Nikolaus Berndt, Michael Mülleder, Eyk Schellenberger, Nicola Beindorff, Dominik N. Müller, Ingolf Sack, Jing Guo, Shraga Nahum Goldberg, Lynn Jeanette Savic   +20 more
wiley   +1 more source

Persistent varices in cured patients: Understanding the role of hepatic venous pressure gradient

JHEP Reports
Background & Aims: Etiologic factor removal (ER) drives recompensation and improves portal hypertension in cirrhosis. Esophageal varices (EV) and portosystemic shunts (PSS) have been found in patients despite hepatic venous pressure gradient (HVPG ...
Pol Olivas, Alexandre Soler-Perromat, Luis Tellez, José Antonio Carrión, Edilmar Alvarado-Tapias, José Ferrusquía-Acosta, Sabela Lens, Antonio Guerrero, Ángeles Falgà, Pamela Vizcarra, Lara Orts, Valeria Perez-Campuzano, Sarah Shalaby, Sonia Torres, Anna Baiges, Fanny Turon, Juan Carlos García-Pagán, Ángeles García-Criado, Virginia Hernández-Gea   +18 more
doaj   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Transjugular intrahepatic portal shunt in the treatment of portal hypertension due to cirrhosis: single center experience

BMC Surgery, 2019
Aim To investigate clinical efficacy of transjugular intrahepatic portal shunt (TIPS) for the treatment of cirrhotic portal hypertension. Methods 71 cases of patients with cirrhotic portal hypertension and esophageal and gastric variceal bleeding ...
Yun Chen, Hanyu Qiu, Xiaomei Zhang
doaj   +1 more source

Comparison Between Conventional Esophagogastroduodenoscopy (EGD) And Endoscopic Ultrasound (EUS) In Prediction of Bleeding from Esophageal and Gastric Varices Due to Portal Hypertension [PDF]

Al-Azhar International Medical Journal
Background: Portal hypertension is increased pressure within the portal venous system. Usually less than or equal to 5mmHg. Portal pressure is measured by a pressure differential between the portal and hepatic veins (or inferior vena cava) of 6mmHg or ...
Alaa Asala, Salwa El-Taher, Ali Soliman, Abeer Aboul Ela   +3 more
doaj   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Endoscopic ultrasound‐guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

Portal Hypertension & Cirrhosis
Aims Portal hypertension (PH) is a complication of cirrhosis that leads to hepatic decompensation. Assessing the portal pressure gradient (PPG) provides valuable information for disease assessment, staging, and prognosis.
Jerome C. Edelson, Scott F. D. Edelson, John G. Quiles, Cyrus V. Edelson, Eric M. Montminy, Christian L. Horn, John P. Magulick, Don C. Rockey   +7 more
doaj   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source