Results 141 to 150 of about 24,071,321 (338)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

CIWS-FW: a Customizable InstrumentWorkstation Software Framework for instrument-independent data handling [PDF]

, 2014
The CIWS-FW is aimed at providing a common and standard solution for the storage, processing and quick look at the data acquired from scientific instruments for astrophysics.
BULGARELLI, ANDREA, CIRAMI, ROBERTO, CIWS Collaboration, CONFORTI, Vito, DADINA, MAURO, FRAILIS, Marco, FRANCESCHI, ENRICO, GIANOTTI, FULVIO, Lodi, M., MORBIDELLI, Roberto, NICASTRO, LUCIANO, Pasian, F., SARTOR, Stefano, SMART, Richard Laurence, TRIFOGLIO, MASSIMO, ZACCHEI, Andrea, Zoli, A.   +16 more
core   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Approaches to Improving the Differential Diagnosis of Acute Portal Venous System Thrombosis

Инновационная медицина Кубани
Background: Thrombosis of the portal venous system remains an insufficiently studied area within abdominal surgery. The relative rarity of the disease, its non-specific clinical presentation, difficulties in instrumental diagnostics, and the mortality ...
T. V. Shevyakova, K. I. Popandopulo, M. B. Andreeva, S. B. Bazlov   +3 more
doaj   +1 more source

A novel approach for portal system reconstruction in liver transplant patients with grade IV portal vein thrombosis: Case study and literature review. [PDF]

Front Transplant, 2022
Qu W, Zhu ZJ, Wei L.
europepmc   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Effects of selective double portazygous disconnection and devascularization on hemodynamics of the portal venous system [PDF]

, 2014
Guang-quan Zong, Yang Fei, Jian Chen, Renmin Liu, Yufeng Xu, N Carbonell, A Pauwels, L Serfaty, O Fourdan, V Levy, R Poupon, P Mccormick, O' Keefe, C, D Sacerdoti, C Merkel, M Bolognesi, Amodio Angeli, P Gatta, A, E Tincani, G Cioni, A Cristani, G Zong, Y Fei, J Chen, R Liu, ; De Franchis, V Baveno, Faculty, J Garca-Pagn, K Caca, C Bureau, M Hassab, F Moriyasu, O Nishida, N Ban, M Bolognesi, D Sacerdoti, C Merkel, C Sabba, G Weltin, D Cicchetti, H El-Serag, J Everhart, R De Franchis, A Dell'era, F Iannuzzi, S Kitano, J Terblanche, J Kahn, P Bornman, T Sato, K Yamazaki, J Toyota, Y Zhang, T Wen, L Yan, M Xie, J Huang, W Pan, G D'amico, Study De Franchis R; Cooperative, Group, M Merli, G Nicolini, S Angeloni, F Gentili, A Attili, O Riggio, L Spahr, J Villeneuve, M Dufresne, J Bosch, A Berzigotti, J Garcia-Pagan, J Abraldes, C Bureau, S Metivier, J Peron, S Raia, S Mies, A Macedo, F Ezzat, K Abu-Elamgd, I Aly, H Huang, C Chang, S Wang, H Nagasaka, T Miida, T Yorifuji, R Charco, J Fuster, C Fondevila, J Ferrer, E Mans, Garca Valdecasas, J, F Fujita   +99 more
openalex   +1 more source

Patient-Caregiver Portal System in Palliative Oncology: Assessment of Usability and Perceived Benefit (Preprint)

, 2023
Margaret L. Longacre, Marcin Chwistek, Cynthia Keleher, Mark Siemon, Brian L. Egleston, Molly Collins, Carolyn Y. Fang   +6 more
openalex   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer

Advanced Science, EarlyView.
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han   +15 more
wiley   +1 more source