Results 191 to 200 of about 956,003 (382)

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

open access: yesCancer Communications, EarlyView.
Abstract Background Phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three‐dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored.
Sunyoung Jang   +9 more
wiley   +1 more source

Prospective intraindividual comparison between respiratory-triggered balanced steady-state free precession and breath-hold gradient-echo and time-of-flight magnetic resonance imaging for assessment of portal and hepatic veins [PDF]

open access: yes, 2018
The purpose of this study was to compare respiratory-triggered balanced steady-state free precession (bSSFP) with breath-hold contrast-enhanced dynamic two-dimensional (2D) gradient-echo (GRE) and time-of-flight (TOF) magnetic resonance imaging (MRI) for
Göpfert, Kerstin   +9 more
core  

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

open access: yesChemMedChem, EarlyView.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore   +5 more
wiley   +1 more source

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan   +6 more
wiley   +1 more source

Advancing Early Clinical Trials: The Transformative Potential of Decentralized Designs and Digital Technologies in Phase 1 Clinical Trial

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
A Phase 1, open‐label, single‐dose, fixed‐sequence crossover study utilizing a hybrid decentralized clinical trial (DCT) design with and without practice sessions for wearable devices and PK sampling was conducted in eight healthy participants. Using etrasimod, the study assessed the feasibility of conducting a Phase 1 hybrid DCT by the Pfizer Clinical
Bimal K. Malhotra   +9 more
wiley   +1 more source

The Impact of Climate Change on the Performance of Agricultural Companies Worldwide

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the impact of climate change on agricultural firms, focusing on physical risks, both chronic (e.g., temperature and precipitation) and acute (e.g., droughts and floods). We conduct a panel data analysis of 19,929 companies in 69 countries across five continents from 2013 to 2021.
Karen Serrano   +3 more
wiley   +1 more source

Portal venous tumor growth-type of hepatocellular carcinoma without liver parenchyma tumor nodules: a case report

open access: yesAnnals of Hepatology, 2013
The patient was a 43-year-old man with chronic hepatitis B without history of hepatocellular carcinoma (HCC), who was first diagnosed with thrombosis in right portal vein trunk and portal vein branches and ruptured esophageal varices in October 2011.
Masaya Saito   +9 more
doaj  

Amelioration of normothermic canine liver ischemia with prostacyclin. [PDF]

open access: yes, 1988
A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia.
ChapChap, P   +10 more
core  

A NEW METHOD FOR CANNULATING THE PORTAL VEIN OF DOGS

open access: hybrid, 1953
A.E. Denton   +2 more
openalex   +1 more source

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