Results 81 to 90 of about 247,498 (312)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Portal venous pulsatility fraction, a novel transesophageal echocardiographic marker for right ventricular dysfunction in cardiac surgical patients

Annals of Cardiac Anaesthesia, 2020
Background: Right ventricular (RV) has a vital role in maintaining optimal tissue perfusion. Assessment of portal venous flow characteristics can be alternative and emerging technique to assess RV function.
Naveen G Singh, Karthik N Kumar, P S Nagaraja, N Manjunatha   +3 more
doaj   +1 more source

Percutaneous Embolization of Congenital Portosystemic Venous Fistula in an Infant with Down Syndrome [PDF]

, 2013
Congenital intrahepatic portosystemic venous shunts are rare vascular malformations often associated with severe complications. We describe a term male infant with Down syndrome with high output heart failure secondary to a congenital arterial to portal ...
Matthew Files, Nghia Vo, Pattaraporn Tanya Chun, Ryan M. McAdams, Terrence Chun   +4 more
core   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Colonic varices treated with embolization after pancreatoduodenectomy with portal vein resection: a case report

Surgical Case Reports, 2020
Background Pancreatoduodenectomy with resection of the portal vein or superior mesenteric vein confluence has been safely performed in patients with pancreatic head cancer associated with infiltration of the portal vein or superior mesenteric vein.
Shota Kuwabara, Joe Matsumoto, Hiroyasu Tojima, Hideyuki Wada, Kohei Kato, Yukiko Tabata, Masaomi Ichinokawa, Tatsuya Yoshioka, Katsuhiko Murakawa, Atsushi Ikeda, Setsuyuki Ohtake, Koichi Ono   +11 more
doaj   +1 more source

Amelioration of normothermic canine liver ischemia with prostacyclin. [PDF]

, 1988
A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia.
ChapChap, P, Demetris, J, Iwatsuki, S, Kamiyama, Y, Makowka, L, Okuda, K, Pan, C, Podesta, L, Starzl, TE, Todo, S, Yokoi, H   +10 more
core  

Aszites, Pfortaderthrombose und hepatische Enzephalopathie bei Leberzirrhose: Aktuelle Therapieempfehlungen [PDF]

, 2012
Treatment of Ascites, Portal Vein Thrombosis and Hepatic Encephalopathy in Patients with Cirrhosis of the Liver Background: Ascites, portal vein thrombosis and hepatic encephalopathy are important complications of cirrhosis of the liver.
Abecasis R, Acosta S, Alexander L. Gerbes, Als-Nielsen B, Als-Nielsen B, Amitrano L, Amitrano L, Amitrano L, Arroyo V, Bajaj JS, Bellot B, Bismuth M, Córdoba J, D'Avola D, de Franchis V, DeLeve LD, Fiaccadori F, Francoz C, Francoz C, Gerbes AL, Gerbes AL, Gerbes AL, Gines P, Gluud LL, Gülberg V, Han G, Häussinger D, Luca A, Montagnese S, Prasad S, Rajani R, Rivkin A, Rosemurgy AS, Rossle M, Rössle M, Salerno F, Salerno F, Salerno F, Sanyal AJ, Senzolo M, Tarantino G, Tublin ME, Veit Gülberg, Wong F, Wong F, Zillikens MC, Zocco MA   +46 more
core   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Value of portal venous system radiological indices in predicting esophageal varices

Clinical and Experimental Gastroenterology, 2015
Vinaya Gaduputi,1 Harish Patel,1 Sailaja Sakam,1 Srivani Neshangi,1 Rafeeq Ahmed,1 Michael Lombino,2 Sridhar Chilimuri11Department of Medicine, 2Department of Radiology, Bronx Lebanon Hospital Center New York, NY, USAIntroduction: Portal hypertension ...
Gaduputi V, Patel H, Sakam S, Neshangi S, Ahmed R, Lombino M, Chilimuri S   +6 more
doaj  

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source