Results 101 to 110 of about 33,834 (215)
Open Questions in Surgery for Hepatoblastoma: A Joined SIOPEL‐IPSO Survey
ABSTRACT Introduction Surgery is pivotal in the management of hepatoblastoma (HB) although approaches and techniques may vary. The Liver Group of the International Society of Pediatric Oncology (SIOPEL) and the International Pediatric Surgical Oncology (IPSO) group collaborated to develop an online survey to investigate specific technical aspects and ...
Chiara Grimaldi +9 more
wiley +1 more source
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal +4 more
wiley +1 more source
ABSTRACT Background and Aims Esophageal varices (EVs) are a common and life‐threatening complication of liver cirrhosis. Endoscopic screening is recommended but remains invasive and resource‐intensive. This study aimed to evaluate the diagnostic performance of the albumin–bilirubin (ALBI) and ALBI–platelet (ALBI–PLT) scores for predicting the presence ...
Thang Dinh Nguyen +2 more
wiley +1 more source
Management of Satellite Lesions in Hepatocellular Carcinoma: An Updated Review
ABSTRACT Satellite lesions, defined as microscopic or small macroscopic tumor nodules within 2 cm of a primary hepatocellular carcinoma (HCC), represent early intrahepatic dissemination and are strongly associated with aggressive tumor biology.
Andy Tran +4 more
wiley +1 more source
Deresuscitation Informed by Ultrasound in Patients With Septic Shock Trial
Objectives The venous excess ultrasound (VExUS) can be used at the point‐of‐care to identify venous overload and end‐organ congestion in an effort to individually tailor resuscitation and deresuscitation in patients with septic shock. Methods We conducted a pilot randomized controlled feasibility trial of VExUS‐guided fluid management in adult patients
Brendan Innes +7 more
wiley +1 more source
Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge +5 more
wiley +1 more source
Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei +9 more
wiley +1 more source
Targeting CD148 for Antithrombotic Therapy: Functional and Molecular Evaluation of AKB‐9778
ABSTRACT CD148 is the primary receptor‐type protein tyrosine phosphatase (PTP) regulating platelet activation, and its inhibition has been proposed as a novel anti‐thrombotic strategy with potentially lower bleeding risk than current therapies. However, selective and potent inhibitors of CD148 are currently lacking.
Lina El Badaoui +3 more
wiley +1 more source

