Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Robust Optimization-Based Commodity Portfolio Performance
This paper examines the performance of a naïve equally weighted buy-and-hold portfolio and optimization-based commodity futures portfolios for various lookback and holding periods using data from January 1986 to December 2018.
Ramesh Adhikari +2 more
doaj +1 more source
Application of an optimization model for constructing an index tracker portfolio and considering the uncertainty of model parameters by using of robust optimization approach [PDF]
index tracking is the process of developing a portfolio that reproduces the performance of an index. The tracker portfolio has relatively good diversity and low turnover and low transaction costs.
Saeid Fallahpour, Farid Tondnevis
doaj +1 more source
Intrinsic Mechanical Parameters and their Characterization in Solid‐State Lithium Batteries
This review focuses on the intrinsic mechanical parameters and their associated characterization in solid‐state batteries. The physical significance of mechanics parameters is introduced with exhaustive classifications by elastic, plastic deformations and fracture in bulk, adhesion, friction at interfaces, and mechanical fatigue in cells ...
Shuai Hao +5 more
wiley +1 more source
Prospect theory-based formulation of chance constrained portfolio optimization problem using loan
Portfolio optimization that allows the borrowed money from a loan to be invested in risk assets has been formulated as a chance constrained problem. In this paper, in order to reflect investor preferences called “values” in the solution, or the portfolio,
Kiyoharu Tagawa, Yukiko Orito
doaj +1 more source
Ex‐Ante Assessment of Farm Resilience to Institutional Shocks: A Modeling Approach
ABSTRACT Using the agent‐based model SWISSland, we simulate farm‐level responses and interactions under two institutional shocks: tariff reductions and direct payment reductions. Using a framework we developed, we assess resilience capacities, resilience attributes, and the provision of private and public goods, following the shock.
Nadja El Benni, Gabriele Mack
wiley +1 more source
Modeling Portfolio Optimization based on behavioral Preferences and Investor’s Memory [PDF]
ObjectiveThe optimization of asset portfolios, taking into account market advancements, has emerged as a pivotal subject in financial economics. Constructing asset portfolios is acknowledged as a critical decision for investors. Consequently, researchers
vahideh mousavi kakhki, Sanaz Khatabi
doaj +1 more source
Differential Evolution for Multiobjective Portfolio Optimization [PDF]
Financial portfolio optimization is a challenging problem. First, the problem is multiobjective (i.e.: minimize risk and maximize profit) and the objective functions are often multimodal and non smooth (e.g.: value at risk).
Thiemo Krink, Sandra Paterlini
core
ABSTRACT This study examines interval selection in the Pasture, Rangeland, and Forage Rainfall Index (PRF‐RI) program and evaluates how uniform premium subsidy rates affect optimal interval selections. Using South Dakota as a case study, we show a trend of increasing selection of nonproduction intervals from 2013 to 2024, raising concerns about program
Whoi Cho, Matthew Diersen
wiley +1 more source
Optimizing Portfolio in the Evolutional Portfolio Optimization System (EPOS)
A novel method of portfolio selection is provided with further higher moments, filtering with fundamentals in intelligent computing resources. The Evolutional Portfolio Optimization System (EPOS) evaluates unobtrusive relations from a vast amount of accounting and financial data, excluding hoax and noise, to select the optimal portfolio.
Nikolaos Loukeris +3 more
openaire +2 more sources

