Results 141 to 150 of about 1,182,692 (300)

2023 AAFP free-roaming cat position statement

open access: yesJournal of Feline Medicine and Surgery, 2023
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Male Hypogonadism: The Korean Society of Men’s Health and Aging Position Statement

open access: yesThe World Journal of Men's Health
The Korean Society of Men’s Health and Aging (KSMHA) acknowledges the necessity for an updated statement on testosterone therapy driven by evolving clinical practices and new research findings.
Sun Tae Ahn   +3 more
doaj   +1 more source

Gender Selection: A Position Statement

open access: yes, 2016
Gender selection is the ability to choose a girl or a boy before you get pregnant. Some methods are used to assist in changing the odds towards the gender being selected. Methods such as selective abortion and infanticide resulted in birth ratios as high
AlKhalili, Batool, Mrayyan, Majd
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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