Results 201 to 210 of about 107,657 (326)

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

The pathway-independent positive allosteric modulator C1 allows for the identification of active Y₄ receptor relevant positions. [PDF]

Cell Mol Life Sci
Schüß C, Vu O, Pelczyk T, Schubert M, Du Y, Stichel J, Weaver CD, Meiler J, Beck-Sickinger AG.   +8 more
europepmc   +1 more source

Peptide‐Ligand Cooperative Interplay Drives Gold Nanoparticle Encapsulation by Protein Cages

Small, EarlyView.
Gold nanoparticle encapsulation within protein cages is governed by salt‐dependent binding energetics and cooperative peptide–ligand interactions. Ligands enhance electrostatic attraction while peptides extend recruitment and prevent kinetic trapping, enabling robust cargo loading. This molecular‐level insight links experiments and simulations, guiding
Wenhui Li, Niklas Mucke, Michael Rütten, Tommaso L. Schweers, Tobias Beck, Vikram Jadhao   +5 more
wiley   +1 more source

Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622

Journal of Pharmacology and Experimental Therapeutics, 2018
Jason M. Uslaner, S. Kuduk, M. Wittmann, Henry S. Lange, Steven V. Fox, C. Min, Natasa Pajkovic, D. Harris, C. Cilissen, C. Mahon, Kate Mostoller, S. Warrington, D. Beshore   +12 more
semanticscholar   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking. [PDF]

Neuropharmacology, 2023
Illenberger JM, Flores-Ramirez FJ, Matzeu A, Lütjens R, Martin-Fardon R.   +4 more
europepmc   +1 more source

Assessing protein‐specific radiation damage in time‐resolved X‐ray solution‐scattering experiments at high‐brilliance synchrotrons using fast detector readout

Acta Crystallographica Section D, EarlyView.
Adenylate kinase was used to quantify how experimental parameters influence radiation damage during time‐resolved X‐ray solution scattering (TR‐XSS) at a multipurpose SAXS beamline. The study provides general guidelines for minimizing radiation artifacts in TR‐XSS.Time‐resolved X‐ray solution scattering (TR‐XSS) enables tracking of protein structural ...
Fatemeh Sabzian-Molaei, Tomás S. Plivelic, Magnus Andersson   +2 more
wiley   +1 more source

Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D₃ Dopamine Receptor. [PDF]

J Med Chem
Moritz AE, Wang F, Madaras NS, Kelley AM, Snyder KK, Gandhi D, Inbody LR, Akano EO, Shi L, Lane JR, Free RB, Frankowski KJ, Sibley DR.   +12 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source