Results 1 to 10 of about 72,363 (158)

Rational engineering of enzyme allosteric regulation through sequence evolution analysis.

PLoS Computational Biology, 2012
Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D) structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an ...
Jae-Seong Yang, Sang Woo Seo, Sungho Jang, Gyoo Yeol Jung, Sanguk Kim   +4 more
doaj   +3 more sources

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy [PDF]

Biomolecules
Human heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore,
Tjaša Goričan, Simona Golič Grdadolnik   +1 more
doaj   +2 more sources

Binding leverage as a molecular basis for allosteric regulation.

PLoS Computational Biology, 2011
Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules.
Simon Mitternacht, Igor N Berezovsky
doaj   +3 more sources

Filamentation modulates allosteric regulation of PRPS

eLife, 2022
Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP.
Huan-Huan Hu, Guang-Ming Lu, Chia-Chun Chang, Yilan Li, Jiale Zhong, Chen-Jun Guo, Xian Zhou, Boqi Yin, Tianyi Zhang, Ji-Long Liu   +9 more
doaj   +3 more sources

Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ [PDF]

Nature Communications
Protein kinase C (PKC) isozymes are ubiquitous kinases that direct diverse cellular pathways and are important drug targets for the treatment of cancer and neurological diseases.
Anh T. Q. Cong, Taylor L. Witter, Elizabeth S. Bruinsma, Sayantani Sarkar Bhattacharya, Swaathi Jayaraman, Samuel R. Wyatt, Jasper K. Solverson, Maria B. Dugan, Jasmina Paluncic, Mary J. Kuffel, Julia R. Alvey, Huy V. Huynh, Xinyan Wu, Alan P. Fields, Akhilesh Pandey, John R. Hawse, Matthew P. Goetz, Matthew J. Schellenberg   +17 more
doaj   +2 more sources

Allosteric regulation of kinase activity [PDF]

eLife
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Amy H Andreotti, Volker Dötsch
doaj   +2 more sources

Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase [PDF]

Nature Communications
Allosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulation in bacteria
Ondřej Bulvas, Zdeněk Knejzlík, Jakub Sýs, Anatolij Filimoněnko, Monika Čížková, Kamila Clarová, Dominik Rejman, Tomáš Kouba, Iva Pichová   +8 more
doaj   +2 more sources

Unveiling Allosteric Regulation and Binding Mechanism of BRD9 through Molecular Dynamics Simulations and Markov Modeling [PDF]

Molecules
Bromodomain-containing protein 9 (BRD9) is a key player in chromatin remodeling and gene expression regulation, and it is closely associated with the development of various diseases, including cancers.
Bin Wang, Jian Wang, Wanchun Yang, Lu Zhao, Benzheng Wei, Jianzhong Chen   +5 more
doaj   +2 more sources

Coevolution-based prediction of key allosteric residues for protein function regulation

eLife, 2023
Allostery is fundamental to many biological processes. Due to the distant regulation nature, how allosteric mutations, modifications, and effector binding impact protein function is difficult to forecast.
Juan Xie, Weilin Zhang, Xiaolei Zhu, Minghua Deng, Luhua Lai   +4 more
doaj   +1 more source

Prediction and confirmation of a switch-like region within the N-terminal domain of hSIRT1

Biochemistry and Biophysics Reports, 2022
Many proteins display conformational changes resulting from allosteric regulation. Often only a few residues are crucial in conveying these structural and functional allosteric changes.
Angelina T. Huynh, Thi-Tina N. Nguyen, Carina A. Villegas, Saira Montemorso, Benjamin Strauss, Richard A. Pearson, Jason G. Graham, Jonathan Oribello, Rohit Suresh, Brooke Lustig, Ningkun Wang   +10 more
doaj   +1 more source