Results 1 to 10 of about 68,403 (252)

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR

Nature Communications
The M5 muscarinic acetylcholine receptor (M5 mAChR) represents a promising therapeutic target for neurological disorders. However, the high conservation of its orthosteric binding site poses significant challenges for drug development.
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal   +13 more
doaj   +1 more source

Allosteric regulation of enzymatic catalysis by molecular crowding. [PDF]

Commun Chem
Ren W, Lu J, Huang H, Zhang J, Chen Y, Yan Z, Li W, Wang W.   +7 more
europepmc   +1 more source

Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP. [PDF]

Nat Commun
Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I.   +7 more
europepmc   +1 more source

Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control. [PDF]

Protein Sci
Kim H, Feng S, Bohutskyi P, Li X, Mejia-Rodriguez D, Zhang T, Qian WJ, Cheung MS.   +7 more
europepmc   +1 more source

Human Transglutaminases: Updated Insights into Activation Mechanisms, Allosteric Regulation and Disease. [PDF]

Int J Mol Sci
Moya-Garrido P, Cano-Gómez LP, Ibarra-Molero B, Godoy-Ruiz R, Medina-Carmona E.   +4 more
europepmc   +1 more source

Allosteric regulation of kinase activity in living cells. [PDF]

Elife, 2023
Godbole SS, Dokholyan NV.
europepmc   +1 more source

Structural basis for the allosteric regulation and catalytic mechanism of Staphylococcus aureus UMP kinase. [PDF]

Front Microbiol
Gao Y, Zhu Z, Wang L, Ke J, Niu L.
europepmc   +1 more source

Allosteric regulation of fibronectin binding by the anti-β1 integrin antibody TS2/16. [PDF]

PNAS Nexus
Ding J, Fantini DA, Dedden D, Schumacher S, Biertümpfel C, Mizuno N.   +5 more
europepmc   +1 more source

Allosteric regulation of prostaglandin endoperoxide H₂ synthases. [PDF]

J Biol Chem
Dong L, Malkowski MG.
europepmc   +1 more source

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity. [PDF]

Cancer Res, 2023
Yang MH, Tran TH, Hunt B, Agnor R, Johnson CW, Shui B, Waybright TJ, Nowak JA, Stephen AG, Simanshu DK, Haigis KM.   +10 more
europepmc   +1 more source