Results 31 to 40 of about 2,237,466 (287)

Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

eLife, 2020
Engineered allosteric regulation of protein activity provides significant advantages for the development of robust and broadly applicable tools. However, the application of allosteric switches in optogenetics has been scarce and suffers from critical ...
Mark Shaaya, Jordan Fauser, Anastasia Zhurikhina, Jason E Conage-Pough, Vincent Huyot, Martin Brennan, Cameron T Flower, Jacob Matsche, Shahzeb Khan, Viswanathan Natarajan, Jalees Rehman, Pradeep Kota, Forest M White, Denis Tsygankov, Andrei V Karginov   +14 more
doaj   +1 more source

Allosteres to regulate neurotransmitter sulfonation [PDF]

Journal of Biological Chemistry, 2019
Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition-cognitive flexibility, aggression, depression, and reward seeking-and manipulating these levels is a major objective of the pharmaceutical industry. Certain neurotransmitters are extensively sulfonated and inactivated by human sulfotransferase 1A3 (SULT1A3).
Kristie, Darrah, Ting, Wang, Ian, Cook, Mary, Cacace, Alexander, Deiters, Thomas S, Leyh   +5 more
openaire   +2 more sources

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I [PDF]

, 2012
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity.
Ruimi, Nili, Martin Ruthardt, Mahajna, Jamal, Khateb, Mamduh, Jamal Mahajna, Ruthardt, Martin, Ottmann, Oliver G., Oliver Gerhard Ottmann, Mian, Afsar Ali, Nili Ruimi, Yousef Najajreh, Afsar Ali Mian, Ottmann, Oliver Gerhard, Susanne Badura, Metodieva, Anna, Najajreh, Yousef, Anna Metodieva, Mamduh Khateb, Badura, Susanne   +18 more
core   +2 more sources

Modeling the contribution of allosteric regulation for flux control in the central carbon metabolism of E. coli

Frontiers in Bioengineering and Biotechnology, 2015
Modeling metabolism is fundamental for cell factory design. Central carbon metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes.
Daniel eMachado, Markus J Herrgard, Isabel eRocha   +2 more
doaj   +1 more source

Modes of allosteric regulation of the ubiquitination machinery [PDF]

Current Opinion in Structural Biology, 2020
Ubiquitination is a post-translational modification crucial for cellular signaling. A diverse range of enzymes constitute the machinery that mediates attachment of ubiquitin onto target proteins. This diversity allows the targeting of various proteins in a highly regulated fashion.
Rennie, Martin L., Chaugule, Viduth K., Walden, Helen   +2 more
openaire   +2 more sources

Emerging maps of allosteric regulation in cellular networks [PDF]

, 2023
Allosteric regulation is classically defined as action at a distance, where a perturbation outside of a protein active site affects function. While this definition has motivated many studies of allosteric mechanisms at the level of protein structure ...
Christopher J.P. Mathy, Kortemme, Tanja, Tanja Kortemme, Mathy, Christopher   +3 more
core   +1 more source

Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures

Nature Communications, 2022
DNA aptamers can activate insulin receptor as selective agonists or positive allosteric modulators. Here, authors determine structures of the insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of ...
Junhong Kim, Na-Oh Yunn, Mangeun Park, Jihan Kim, Seongeun Park, Yoojoong Kim, Jeongeun Noh, Sung Ho Ryu, Yunje Cho   +8 more
doaj   +1 more source

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]

, 2011
Background: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome.
Mahajna, Jamal, Y. Najajreh, Ruthardt, Martin, M. Ruthardt, Ottmann, Oliver G., J. Mahajna, Mian, Afsar Ali, Mian, Afsar A., Metodieva, Anna, Najajreh, Yousef, A. Metodieva, A. A. Mian, O. G. Ottmann   +12 more
core   +1 more source

Engineering and exploiting synthetic allostery of NanoLuc luciferase

Nature Communications, 2022
Allosteric regulation of proteins allows transduction and interconversion of biochemical signals. Here the authors construct an allosteric version of circular permutated NanoLuc that can be activated by a ligand; they use this to create biosensors to ...
Zhong Guo, Rinky D. Parakra, Ying Xiong, Wayne A. Johnston, Patricia Walden, Selvakumar Edwardraja, Shayli Varasteh Moradi, Jacobus P. J. Ungerer, Hui-wang Ai, Jonathan J. Phillips, Kirill Alexandrov   +10 more
doaj   +1 more source

Allosteric regulation of phenylalanine hydroxylase [PDF]

Archives of Biochemistry and Biophysics, 2012
The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin.
openaire   +2 more sources