Results 21 to 30 of about 2,237,466 (287)
Co-transcriptional allosteric regulation of synthetic nucleic acid receptors [PDF]
, 2023 We present a strategy to control allosterically the loading and release of molecular ligands from synthetic nucleic acid receptors using in vitro transcription.
Eiji, Nakamura +4 more
core +2 more sources
Frontiers in Molecular Biosciences, 2020 Allosteric regulation is a common mechanism employed by complex biomolecular systems for regulation of activity and adaptability in the cellular environment, serving as an effective molecular tool for cellular communication.
Gennady M. Verkhivker +4 more
doaj +1 more source
Multiple conformations in solution of the maize C4-phosphoenolpyruvate carboxylase isozyme
Heliyon, 2021 The photosynthetic phosphoenolpyruvate carboxylase isozyme from C4 plants (PEPC-C4) has a complex allosteric regulation, involving positive cooperativity in binding the substrate phosphoenolpyruvate as well as positive and negative allosteric effectors ...
Fátima Barreda-Huerta +3 more
doaj +1 more source
Design of an allosterically regulated retroaldolase [PDF]
Protein Science, 2015 AbstractWe employed a minimalist approach for design of an allosterically controlled retroaldolase. Introduction of a single lysine residue into the nonenzymatic protein calmodulin led to a 15,000‐fold increase in the second order rate constant for retroaldol reaction with methodol as a substrate.
Elizabeth A, Raymond +5 more
openaire +2 more sources
Molecular Structure Underlying the Allosteric Mechanism of Caffeine Detection in Taste Sensor
Chemosensors, 2023 The use of taste sensors with lipid/polymer membranes is one of the methods to evaluate taste. As previously reported, taste sensors can detect non-charged substances such as caffeine by modifying the lipid/polymer membranes with hydroxybenzoic acids ...
Hengwei Xu +4 more
doaj +1 more source
Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication. [PDF]
PLoS Computational Biology, 2017 Allosteric interactions in the Hsp70 proteins are linked with their regulatory mechanisms and cellular functions. Despite significant progress in structural and functional characterization of the Hsp70 proteins fundamental questions concerning modularity
Gabrielle Stetz, Gennady M Verkhivker
doaj +1 more source
Prospects for the use of allosteric drugs in real-world clinical practice
Реальная клиническая практика: данные и доказательства, 2023 While the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic ...
I. R. Svechkareva, A. S. Kolbin
doaj +1 more source
Metabolic Engineering Communications, 2020 The present study attempted a computer simulation of the metabolism of a model cyanobacteria, Synechocystis sp. PCC 6803 (PCC 6803) to predict allosteric inhibitions that are likely to occur in photoautotrophic and mixotrophic conditions as well as in a ...
Hiroki Nishiguchi +3 more
doaj +1 more source
Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]
, 2007 Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core +1 more source
Molecules, 2020 In recent years, new drug discovery approaches based on novel pharmacological concepts have emerged. Allosteric modulators, for example, target receptors at sites other than the orthosteric binding sites and can modulate agonist-mediated activation ...
Víctor Fernández-Dueñas +6 more
doaj +1 more source