Results 41 to 50 of about 2,237,466 (287)

Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex

Nature Communications, 2021
The allosteric regulation of the bienzyme complex imidazole glycerol phosphate synthase (HisFH) remains to be elucidated. Here, the authors provide structural insights into the dynamic allosteric mechanism by which ligand binding to the cyclase and ...
Jan Philip Wurm, Sihyun Sung, Andrea Christa Kneuttinger, Enrico Hupfeld, Reinhard Sterner, Matthias Wilmanns, Remco Sprangers   +6 more
doaj   +1 more source

Allosteric modulation of G protein-coupled receptor signaling

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins, regulate a wide array of physiological processes in response to extracellular signals. Although these receptors have proven to be the most successful class of drug targets,
Siyuan Shen, Chang Zhao, Chao Wu, Suyue Sun, Ziyan Li, Wei Yan, Zhenhua Shao   +6 more
doaj   +1 more source

Computational modeling of cAMP­-dependent protein kinase allostery [PDF]

Proceedings of the Estonian Academy of Sciences, 2023
Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was com­putationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
doaj   +1 more source

What is allosteric regulation? Exploring the exceptions that prove the rule! [PDF]

Journal of Biological Chemistry
Aron W Fenton, Clarissa L Durie, Tonya N Zeczycki   +2 more
exaly   +2 more sources

Allosteric regulation of Argonaute proteins by miRNAs [PDF]

Nature Structural & Molecular Biology, 2010
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of
Sergej, Djuranovic, Michelle Kim, Zinchenko, Junho K, Hur, Ali, Nahvi, Julie L, Brunelle, Elizabeth J, Rogers, Rachel, Green   +6 more
openaire   +2 more sources

Computational study on the inhibitor binding mode and allosteric regulation mechanism in hepatitis C virus NS3/4A protein.

PLoS ONE, 2014
HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication.
Weiwei Xue, Ying Yang, Xiaoting Wang, Huanxiang Liu, Xiaojun Yao   +4 more
doaj   +1 more source

Discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation. [PDF]

PLoS ONE, 2012
A novel approach to reveal intramolecular signal transduction network is proposed in this work. To this end, a new algorithm of network construction is developed, which is based on a new protein dynamics model of energy dissipation. A key feature of this
Cheng-Wei Ma, Zhi-Long Xiu, An-Ping Zeng
doaj   +1 more source

Dimeric allostery mechanism of the plant circadian clock photoreceptor ZEITLUPE.

PLoS Computational Biology, 2021
In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock.
Francesco Trozzi, Feng Wang, Gennady Verkhivker, Brian D Zoltowski, Peng Tao   +4 more
doaj   +1 more source

Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect

Frontiers in Molecular Biosciences, 2022
The Ras-specific guanine nucleotide exchange factors Son of Sevenless (SOS) regulates Ras activation by converting inactive GDP-bound to active GTP-bound states.
Xuan He, Kui Du, Yuanhao Wang, Jigang Fan, Mingyu Li, Duan Ni, Shaoyong Lu, Shaoyong Lu, Xiaolan Bian, Yaqin Liu   +9 more
doaj   +1 more source

The energy landscape analysis of cancer mutations in protein kinases. [PDF]

PLoS ONE, 2011
The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases.
Anshuman Dixit, Gennady M Verkhivker
doaj   +1 more source