Results 41 to 50 of about 68,671 (251)

Allosteric regulation of rhomboid intramembrane proteolysis [PDF]

The EMBO Journal, 2014
Proteolysis within the lipid bilayer is poorly understood, in particular the regulation of substrate cleavage. Rhomboids are a family of ubiquitous intramembrane serine proteases that harbour a buried active site and are known to cleave transmembrane substrates with broad specificity.
Elena, Arutyunova, Pankaj, Panwar, Pauline M, Skiba, Nicola, Gale, Michelle W, Mak, M Joanne, Lemieux   +5 more
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Pathways of allosteric regulation in Hsp70 chaperones [PDF]

Nature Communications, 2015
AbstractCentral to the protein folding activity of Hsp70 chaperones is their ability to interact with protein substrates in an ATP-controlled manner, which relies on allosteric regulation between their nucleotide-binding (NBD) and substrate-binding domains (SBD).
Roman Kityk, Markus Vogel, Rainer Schlecht, Bernd Bukau, Matthias P. Mayer   +4 more
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The energy landscape analysis of cancer mutations in protein kinases. [PDF]

PLoS ONE, 2011
The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases.
Anshuman Dixit, Gennady M Verkhivker
doaj   +1 more source

Allosteric Regulation of E-Cadherin Adhesion [PDF]

Journal of Biological Chemistry, 2015
Cadherins are transmembrane adhesion proteins that maintain intercellular cohesion in all tissues, and their rapid regulation is essential for organized tissue remodeling. Despite some evidence that cadherin adhesion might be allosterically regulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding affinity
Nitesh, Shashikanth, Yuliya I, Petrova, Seongjin, Park, Jillian, Chekan, Stephanie, Maiden, Martha, Spano, Taekjip, Ha, Barry M, Gumbiner, Deborah E, Leckband   +8 more
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Hairpin and allosteric regulation in ADAMTS13 [PDF]

Blood, 2019
In this issue of Blood , Muia et al 1 and Zhu et al, 2 using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity ...
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Allosteric regulation of epigenetic modifying enzymes [PDF]

Current Opinion in Chemical Biology, 2017
Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attractive opportunities for therapeutic development. Recent
Beth E, Zucconi, Philip A, Cole
openaire   +2 more sources

Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions

Molecules, 2021
DNA methyltransferases (DNMTs) including DNMT1 are a conserved family of cytosine methylases that play crucial roles in epigenetic regulation. The versatile functions of DNMT1 rely on allosteric networks between its different interacting partners ...
Yu Zhu, Fei Ye, Ziyun Zhou, Wanlin Liu, Zhongjie Liang, Guang Hu   +5 more
doaj   +1 more source

Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets

Frontiers in Molecular Biosciences, 2020
Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric sites that would be used as ...
Merve Ayyildiz, Serkan Celiker, Fatih Ozhelvaci, E. Demet Akten   +3 more
doaj   +1 more source

Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR

Nature Communications
Allosteric drugs offer a new avenue for modern drug design. However, the identification of cryptic allosteric sites presents a formidable challenge. Following the allostery nature of residue-driven conformation transition, we propose a state-of-the-art ...
Xin Chen, Kexin Wang, Jianfang Chen, Chao Wu, Jun Mao, Yuanpeng Song, Yijing Liu, Zhenhua Shao, Xuemei Pu   +8 more
doaj   +1 more source

FimH as a scaffold for regulated molecular recognition

Journal of Biological Engineering, 2021
Background Recognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks convenient regulation.
Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko, Wendy Evelyn Thomas   +5 more
doaj   +1 more source