Results 41 to 50 of about 68,403 (252)
Computational modeling of cAMP-dependent protein kinase allostery [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Allosteric regulation by ATP of peptide binding with a cAMP-dependent protein kinase catalytic subunit was comÂputationally modeled by combining conventional docking analysis and molecular dynamics calculations.
Andrei Izvolski, Aleksei Kuznetsov
doaj +1 more source
Engineering and exploiting synthetic allostery of NanoLuc luciferase
Nature Communications, 2022 Allosteric regulation of proteins allows transduction and interconversion of biochemical signals. Here the authors construct an allosteric version of circular permutated NanoLuc that can be activated by a ligand; they use this to create biosensors to ...
Zhong Guo +10 more
doaj +1 more source
Allosteric regulation of Argonaute proteins by miRNAs [PDF]
Nature Structural & Molecular Biology, 2010 Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of
Sergej, Djuranovic +6 more
openaire +2 more sources
PLoS ONE, 2014 HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication.
Weiwei Xue +4 more
doaj +1 more source
Discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation. [PDF]
PLoS ONE, 2012 A novel approach to reveal intramolecular signal transduction network is proposed in this work. To this end, a new algorithm of network construction is developed, which is based on a new protein dynamics model of energy dissipation. A key feature of this
Cheng-Wei Ma, Zhi-Long Xiu, An-Ping Zeng
doaj +1 more source
Allosteric modulation of G protein-coupled receptor signaling
Frontiers in Endocrinology, 2023 G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins, regulate a wide array of physiological processes in response to extracellular signals. Although these receptors have proven to be the most successful class of drug targets,
Siyuan Shen +6 more
doaj +1 more source
Allosteric regulation of rhomboid intramembrane proteolysis [PDF]
The EMBO Journal, 2014 Abstract Proteolysis within the lipid bilayer is poorly understood, in particular the regulation of substrate cleavage. Rhomboids are a family of ubiquitous intramembrane serine proteases that harbour a buried active site and are known to cleave transmembrane substrates with broad specificity ...
Elena, Arutyunova +5 more
openaire +2 more sources
Dimeric allostery mechanism of the plant circadian clock photoreceptor ZEITLUPE.
PLoS Computational Biology, 2021 In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock.
Francesco Trozzi +4 more
doaj +1 more source
Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect
Frontiers in Molecular Biosciences, 2022 The Ras-specific guanine nucleotide exchange factors Son of Sevenless (SOS) regulates Ras activation by converting inactive GDP-bound to active GTP-bound states.
Xuan He +9 more
doaj +1 more source
Pathways of allosteric regulation in Hsp70 chaperones [PDF]
Nature Communications, 2015 AbstractCentral to the protein folding activity of Hsp70 chaperones is their ability to interact with protein substrates in an ATP-controlled manner, which relies on allosteric regulation between their nucleotide-binding (NBD) and substrate-binding domains (SBD).
Roman Kityk +4 more
openaire +2 more sources