Results 51 to 60 of about 2,237,466 (287)

Hairpin and allosteric regulation in ADAMTS13 [PDF]

Blood, 2019
In this issue of Blood , Muia et al 1 and Zhu et al, 2 using complementary approaches, provide important insights into the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1 repeats, member 13), identifying critical structural features and interactions that allosterically regulate its proteolytic activity ...
openaire   +2 more sources

Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair [PDF]

, 2012
The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment.
Susan McIntyre, Mcintyre, Susan, Mark Marsden, Rehab AlJamal-Naylor, Fiona Rossi, Harrison, Beth, Marsden, Mark, Linda Wilson, Aljamal-naylor, Rehab, Wilson, Linda, David J. Harrison, Beth Harrison, Rossi, Fiona, Harrison, David J.   +13 more
core   +1 more source

Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions

Molecules, 2021
DNA methyltransferases (DNMTs) including DNMT1 are a conserved family of cytosine methylases that play crucial roles in epigenetic regulation. The versatile functions of DNMT1 rely on allosteric networks between its different interacting partners ...
Yu Zhu, Fei Ye, Ziyun Zhou, Wanlin Liu, Zhongjie Liang, Guang Hu   +5 more
doaj   +1 more source

Allosteric regulation of glutamate dehydrogenase deamination activity. [PDF]

, 2020
Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, hyperinsulinism/hyperammonemia (HI/HA) syndrome, and neurodegenerative diseases have  ...
Chakraborty, Amit, Sljoka, Adnan, Sun, Gui-Quan, Li, B Larry, Medvinsky, Alexander, Acquisti, Claudia, Bera, Soumen, Rashid, Mubasher   +7 more
core   +1 more source

Unraveling the Allosteric Cross-Talk Between Coactivator Peptide and Ligand Binding Site in Glucocorticoid Receptor [PDF]

, 2021
Glucocorticoid receptor (GR) is a nuclear receptor that controls critical biological processes by regulating thetranscription of specific genes. There is a known allosteric cross-talk between the ligand and coregulator bindingsites within the GR ligand ...
Giuseppina, La Sala, Andrey, Frolov, Christian, Tyrchan, Anders, Gunnarsson, karl, edman, anders, hogner   +5 more
core   +1 more source

Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets

Frontiers in Molecular Biosciences, 2020
Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric sites that would be used as ...
Merve Ayyildiz, Serkan Celiker, Fatih Ozhelvaci, E. Demet Akten   +3 more
doaj   +1 more source

The structure and allosteric regulation of glutamate dehydrogenase [PDF]

Neurochemistry International, 2011
Glutamate dehydrogenase (GDH) has been extensively studied for more than 50 years. Of particular interest is the fact that, while considered by most to be a 'housekeeping' enzyme, the animal form of GDH is heavily regulated by a wide array of allosteric effectors and exhibits extensive inter-subunit communication.
Ming, Li, Changhong, Li, Aron, Allen, Charles A, Stanley, Thomas J, Smith   +4 more
openaire   +2 more sources

Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR

Nature Communications
Allosteric drugs offer a new avenue for modern drug design. However, the identification of cryptic allosteric sites presents a formidable challenge. Following the allostery nature of residue-driven conformation transition, we propose a state-of-the-art ...
Xin Chen, Kexin Wang, Jianfang Chen, Chao Wu, Jun Mao, Yuanpeng Song, Yijing Liu, Zhenhua Shao, Xuemei Pu   +8 more
doaj   +1 more source

FimH as a scaffold for regulated molecular recognition

Journal of Biological Engineering, 2021
Background Recognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks convenient regulation.
Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko, Wendy Evelyn Thomas   +5 more
doaj   +1 more source

Pathways of allosteric regulation in Hsp70 chaperones [PDF]

Nature Communications, 2015
AbstractCentral to the protein folding activity of Hsp70 chaperones is their ability to interact with protein substrates in an ATP-controlled manner, which relies on allosteric regulation between their nucleotide-binding (NBD) and substrate-binding domains (SBD).
Roman Kityk, Markus Vogel, Rainer Schlecht, Bernd Bukau, Matthias P. Mayer   +4 more
openaire   +2 more sources