Results 11 to 20 of about 68,403 (252)
Frontiers in Molecular Biosciences, 2020 Allosteric regulation is a common mechanism employed by complex biomolecular systems for regulation of activity and adaptability in the cellular environment, serving as an effective molecular tool for cellular communication.
Gennady M Verkhivker +2 more
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Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy. [PDF]
BiomoleculesHuman heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore,
Goričan T, Golič Grdadolnik S.
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Full-length nuclear receptor allosteric regulation. [PDF]
J Lipid Res, 2023 Nuclear receptors are a superfamily of transcription factors regulated by a wide range of lipids that include phospholipids, fatty acids, heme-based metabolites, and cholesterol-based steroids. Encoded as classic two-domain modular transcription factors,
Choi WJ, Haratipour Z, Blind RD.
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Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
PLoS Computational Biology, 2012 Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D) structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an ...
Jae-Seong Yang +2 more
exaly +3 more sources
Binding Leverage as a Molecular Basis for Allosteric Regulation
PLoS Computational Biology, 2011 Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules.
Simon Mitternacht, Igor N Berezovsky
exaly +3 more sources
Frontiers in Bioengineering and Biotechnology, 2015 Modeling metabolism is fundamental for cell factory design. Central carbon metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes.
Daniel Machado +2 more
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Allosteric regulation of kinase activity. [PDF]
ElifeThe articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Andreotti AH, Dötsch V.
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Deciphering the allosteric regulation of mycobacterial inosine-5'-monophosphate dehydrogenase. [PDF]
Nat CommunAllosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulation in bacteria
Bulvas O +8 more
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Filamentation modulates allosteric regulation of PRPS
eLife, 2022 Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP.
Huan-Huan Hu +9 more
doaj +3 more sources
Unveiling Allosteric Regulation and Binding Mechanism of BRD9 through Molecular Dynamics Simulations and Markov Modeling. [PDF]
MoleculesBromodomain-containing protein 9 (BRD9) is a key player in chromatin remodeling and gene expression regulation, and it is closely associated with the development of various diseases, including cancers.
Wang B +5 more
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