Results 31 to 40 of about 31,985 (308)
Positive Allosteric Modulators of Nicotinic Acetylcholine Receptor [PDF]
ACS Medicinal Chemistry Letters, 2013 Priority Application: Priority date: July 8, 2011 Inventors: Eskildsen, J.; Sams, A. G.; Pueschl, A. Assignee Company: H. Lundbeck A/S, Den. Disease Area: autism, neurodegenerative diseases Biological Target: nicotinic acetylcholine receptor α7 (α7 nAChR) Summary: The patent application claims cyclopropylcarboxamide derivatives as positive allosteric ...
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Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]
, 2017 Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone +4 more
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Nature Communications, 2023 TRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for long-
Heng Zhang +8 more
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Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors [PDF]
The Journal of Neuroscience, 2005 Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as Alzheimer's disease and show promise in the treatment of depression.
Rongsheng, Jin +5 more
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Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) [PDF]
, 2015 ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S.
Cascio, Maria G. +12 more
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GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity. [PDF]
, 2017 Positive modulation of the GABAB receptor (GABABR) represents a potentially useful therapeutic approach for the treatment of nicotine addiction. The positive allosteric modulators (PAMs) of GABABR GS39783 and BHF177 enhance GABA-stimulated [35S]GTP γS ...
Cameron, Michael +8 more
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Effects of insecticidal ketones present in mint plants on GABA A receptor from mammalian neurons [PDF]
, 2017 The genus Mentha, an important member of the Lamiaceae family, is represented by many species commonly known as mint. The insecticidal activity of Mentha oil and its main components has been tested and established against various insects/pests.
Delgado Marín, Leticia Ester +2 more
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4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator
Journal of Pharmacological Sciences, 2017 Acid-sensing ion channels (ASICs) are proton-sensitive sodium channels that open in response to lowered extracellular pH and are expressed in the central and peripheral nervous systems.
Amruta S. Agharkar, Eric B. Gonzales
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Acta Biochimica et Biophysica Sinica, 2022 As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity.
Fan Guangchun +4 more
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Neuropsychopharmacology Reports, 2023 Binge‐like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal‐diencephalic‐cingulate memory network. This is
Clark W. Bird, Carlos F. Valenzuela
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