Results 91 to 100 of about 1,950,871 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Alternative methods for representing the inverse of linear programming basis matrices

, 1988
Methods for representing the inverse of Linear Programming (LP) basis matrices are closely related to techniques for solving a system of sparse unsymmetric linear equations by direct methods.
Mitra, G, Tamiz, M
core  

Integrated Multi-Omics Reveals the Molecular Basis Underlying Wheat Grain Development and Identifies TaYAK1-2D as a Positive Grain Weight Regulator

Plants
Grain weight, a highly heritable yield component, is a primary breeding target for enhancing wheat productivity. Unraveling the molecular dynamics underlying grain development is essential for identifying key regulators controlling this trait.
Yazhou Xuan, Ling Zhao, Yinuo Li, Shujing Guo, Yuxue Pan, Liuge Xue, Hualiang Qiao, Wenzhao Xie, Lin Guo, Baowen Zhang, Shuzhi Zheng, Xigang Liu, Wenqiang Tang, Chunjiang Zhou, Lei Wang, Jun Ji, Junming Li, Hong Liu   +17 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Positive-energy spectra of atomic hydrogen in a magnetic field: A comparative study between different theoretical approaches

, 2021
The problem of photoionization of atomic hydrogen in a white-dwarf-strength magnetic field is revisited to understand the existing discrepancies in the positive-energy spectra obtained by a variety of theoretical approaches reported in the literature ...
Bartschat, K, Wang, KD, Zhao, LB
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Time-Varying Risk Premia in the Foreign Currency Futures Basis [PDF]

Significant time-varying risk premia exist in the foreign currency futures basis, and these risk premia are meaningfully correlated with common macroeconomic risk factors from equity and bond markets.
Christopher F. Baum, John Barkoulas
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial

, 2010
Background: It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of patients suffering from psychosis.
Andreas Bechdolf, Wölwer, Wolfgang, Buchkremer Gerhard, Klingberg, Stefan, Tilo Kircher, Bernhard W Müller, Engel Corinna, Bechdolf Andreas, Klingberg Stefan, Wagner Michael, Engel, Corinna, Buchkremer, Gerhard, Corinna Engel, Wittorf, Andreas, Meisner Christoph, Christoph Meisner, Sartory, Gudrun, Wiedemann, Georg, Michael Wagner, Müller, Bernhard W., Sartory Gudrun, Wagner, Michael, Meisner, Christoph, Stefan Klingberg, Georg Wiedemann, Wiedemann Georg, Herrlich Jutta, Wittorf Andreas, Jutta Herrlich, König Hans-Helmut, Herrlich, Jutta, Andreas Wittorf, Wolfgang Wölwer, König, Hans-Helmut, Bechdolf, Andreas, Kircher Tilo, Wölwer Wolfgang, Kircher, Tilo, Hans-Helmut König, Gerhard Buchkremer, Gudrun Sartory, Müller Bernhard W   +41 more
core   +1 more source

Formation of a Positive Image of People with Disabilities in Modern Russian Media as the Basis for their Social Inclusion

Дискурс
Introduction. The social policy of the Russian state is aimed at involving socially vulnerable groups of the population in all spheres of social life. One of the most important mechanisms of social inclusion is the formation of a positive image of people
Ya. A. Margyan, Ya. S. Rocheva, A. L. Shavonin   +2 more
doaj   +1 more source