Results 71 to 80 of about 1,950,871 (308)
How the selection of training patterns can improve the generalization capability in Radial Basis Neural Networks [PDF]
, 2003 It has been shown that the selection of the most similar training patterns to generalize a new sample can improve the generalization capability of Radial Basis Neural Networks. In previous works, authors have proposed a learning method that automatically
Galván, Inés M. +2 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Radial basis function based meshless methods for fluid flow problems
, 2006 This thesis is concerned with the development of meshless methods using radial basis functions for solving fluid flow problems. The advantage of meshless methods over traditional mesh-based methods is that they make use of a scattered set of collocation ...
Chinchapatnam, Phani P. +1 more
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Invariant subspaces for positive operators on Banach spaces with unconditional basis
, 2022 We prove that every lattice homomorphism acting on a Banach space with the lattice structure given by an unconditional basis has a non-trivial closed invariant subspace.
Gallardo Gutiérrez, Eva A. +7 more
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Clocks & SleepThe regularity of sleep–wake cycles is a defining characteristic of normative sleep patterns that are typically associated with proper circadian rhythmicity. The previous literature indicates that consistent patterns of sleep and wake are associated with
David Negelspach +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Using positive psychology measures in clinical practice: reliability and validity in an Australian population [PDF]
, 2014 Introduction: Mental health is usually considered from a medical perspective, with a focus on the diagnosis and management of illness and psychological distress.
Hennessy, Maria
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