Results 61 to 70 of about 1,950,871 (308)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers [PDF]

, 2013
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Luca Gianni, Del Conte, Gianluca, Sotiriou, Christos, Pusztai, Lajos, Lajos Pusztai, Karn, Thomas, Symmans, W. Fraser, Libero Santarpia, Volkmar Müller, Santarpia, Libero, Sven Becker, Milvia Zambetti, Müller, Volkmar, Symmans, W Fraser, Benjamin Haibe-Kains, Kelly, Catherine M, Rody, Achim, Catherine M Kelly, Giampaolo Bianchini, Marcus Schmidt, Gianluca Del Conte, Gianni, Luca, Bianchini, Giampaolo, W Fraser Symmans, Haibe-Kains, Benjamin, Thomas Karn, Achim Rody, Schmidt, Marcus, Fasolo, Angelica, Takayuki Iwamoto, Angelica Fasolo, Holtrich, Uwe, Kelly, Catherine M., Yuan Qi, Christos Sotiriou, Uwe Holtrich, Iwamoto, Takayuki, Qi, Yuan, Becker, Sven, Zambetti, Milvia   +39 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On the number of representations of positive integers by quadratic forms as the basis of the space S4(Γ0(47),1)

International Journal of Mathematics and Mathematical Sciences, 2004
The number of representations of positive integers by quadratic forms F1=x12+x1x2+12x22 and G1=3x12+x1x2+4x22 of discriminant −47 are given. Moreover, a basis for the space S4(Γ0(47),1) are constructed, and the formulas for r(n;F4), r(n;G4), r(n;F3⊕G1),
Ahmet Tekcan, Osman Bızım
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization

Nature Communications
The metabotropic glutamate receptors (mGluRs) are neuromodulatory family C G protein coupled receptors which assemble as dimers and allosterically couple extracellular ligand binding domains (LBDs) to transmembrane domains (TMDs) to drive intracellular ...
Alexa Strauss, Alberto J. Gonzalez-Hernandez, Joon Lee, Nohely Abreu, Purushotham Selvakumar, Leslie Salas-Estrada, Melanie Kristt, Anisul Arefin, Kevin Huynh, Dagan C. Marx, Kristen Gilliland, Bruce J. Melancon, Marta Filizola, Joel Meyerson, Joshua Levitz   +14 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Molecular basis of positional memory in limb regeneration

Nature
Abstract The amputation of a salamander limb triggers anterior and posterior connective tissue cells to form distinct signalling centres that together fuel regeneration1. Anterior and posterior identities are established during development and are thought to persist for the whole life in the form of positional memory2.
L. Otsuki, S. A. Plattner, Y. Taniguchi-Sugiura, F. Falcon, E. M. Tanaka   +4 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source