Results 91 to 100 of about 19,606,816 (280)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Positive body image: inter-ethnic and rural-urban differences among an indigenous sample from Malaysian Borneo

, 2011
Background: Previous studies examining body image from a cross-cultural perspective have tended to neglect samples from different ethnic groups or along a rural-urban continuum.
Swami, V., Kannan, K., Kumaraswami Kannan, Viren Swami, Furnham, A., Adrian Furnham   +5 more
core   +1 more source

Systematic review of body image measures [PDF]

, 2019
Contains fulltext : 207725.pdf (Publisher’s version ) (Open Access)This systematic review synthesizes and critically appraises measurement properties of influential body image measures.
Silva, A.G., Kwakkenbos, L., Dooley, Barbara, Dooley, B., Rodgers, Rachel F., Kwakkenbos, Linda, Diedrichs, P.C., Kling, Johanna, Silva, Anabela, Rumsey, Nichola, Rumsey, N., Fitzgerald, A., Silva, Anabela G., Frisén, Ann,, Brandão, M.P., Fitzgerald, Amanda, Frisén, A., Rodgers, R.F., Fris�n, Ann, Brandão, Maria Piedade, Kling, Johanna,, Diedrichs, Phillippa C., Kling, J., Brand�o, Maria Piedade, Diedrichs, Phillippa   +24 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

More than my Appearance: a pilot evaluation of the Expand Your Horizon online functionality-based writing programme for adults with visible differences

Health Psychology and Behavioral Medicine
Background Adults with conditions that affect their appearance, known as visible differences, can experience appearance concerns, social anxiety, and depression.
Ella Guest, Emma Halliwell, Abbi Mathews, Jessica M. Alleva, Diana Harcourt   +4 more
doaj   +1 more source

"I bet they aren't that perfect in reality:" Appearance ideals viewed from the perspective of adolescents with a positive body image

, 2012
In this qualitative study, we examined the topic of appearance ideals from the perspective of 14-year-old adolescents (N=29) with a positive body image.
Frisén, Ann,, Holmqvist, Kristina,
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Body appreciation and resilience are associated with self-esteem among women competing in fitness and bodybuilding: a cross-sectional study

Frontiers in Sports and Active Living
IntroductionWomen who compete in fitness and bodybuilding participate in a sporting culture where muscularity, leanness, symmetry, and presentation are judged directly.
Irene Barbero-Alcocer, Javier González-del-Castillo, Noelia Carbonell-Bernal   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A randomized experimental evaluation of a yoga-based body image intervention [PDF]

, 2019
Recent literature argues that body image interventions need to become more embodied. This paper evaluates a brief yoga-based body image intervention which incorporates themes specifically tailored to focus on positive body image. Young women (Mage= 20.21,
Dawson, Kayleigh, Burkey, Samantha, Halliwell, Emma   +2 more
core   +1 more source