Results 111 to 120 of about 19,606,816 (280)

The effects of Nirvana fitness and functional training on the body appreciation of young women: non-randomized controlled trial

Frontiers in Psychology
IntroductionExercise is an important intervention used to improve body image. The present non-randomized controlled trial aimed to examine the effects of Nirvana Fitness (NF) and functional training (FT) on body appreciation and its correlates in young ...
Rasa Jankauskiene, Vaiva Balciuniene, Renata Rutkauskaite, Simona Pajaujiene, Migle Baceviciene   +4 more
doaj   +1 more source

Looking age-appropriate while growing old gracefully: A qualitative study of ageing and body image among older adults [PDF]

, 2014
Body dissatisfaction can be significantly detrimental to wellbeing. Little is known about older adults’ body image, despite the fact that ageing causes unique bodily changes and that sociocultural pressures to resist these changes abound.
Williamson, Heidi, Christopher, Gary, Harcourt, D, Diedrichs, Phillippa C., Jankowski, Glen S., Williamson, H, Jankowski, G, Harcourt, Diana, Christopher, G, Diedrichs, PC, Gary Christopher   +10 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Redefining Body-Self Relationships Through Outdoor Physical Activity: Experiences of Women Navigating Illness, Injury, and Disability

Behavioral Sciences
Physical challenges such as illness, injury, and disability significantly alter women’s relationships with their bodies, disrupting established notions of functionality and self-worth.
Joelle Breault-Hood, Tonia Gray, Jacqueline Ullman, Son Truong   +3 more
doaj   +1 more source

Effect of the Parent–Adolescent Relationship on Adolescent Boys’ Body Image and Subjective Well-Being

American Journal of Men's Health, 2017
Adolescent boys must cope with physical changes that hamper their ability to form a positive body image. Sociocultural messages influence the concepts of body image, personal appearance, and weight, encouraging men to develop lean and muscular bodies ...
Ofra Walter PhD, Vered Shenaar-Golan PhD
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Translation and Validation of the Functionality Satisfaction and the Functionality Intent Scales in a French Sample

European Journal of Investigation in Health, Psychology and Education
Body functionality is a promising target for the promotion of positive body image. However, research on body functionality in French-language contexts is currently limited due to the lack of validated assessment tools.
Eva Roy, Alain Guerrien, Claire Arnaud, Rachel F. Rodgers, Amélie Rousseau   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source