Results 31 to 40 of about 19,694 (262)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
ActuatorsCurrent trends in the development of technology are linked inextricably to the increasing level of automation in technological processes and production systems. In this regard, the development of systems for supplying working fluids with adjustable pumps
Alexey N. Beskopylny +3 more
doaj +1 more source
Polish Maritime Research, 2019 In this paper, volumetric losses in a positive displacement pump supplied with water and mineral oil are described and compared. The experimental tests were conducted using a prototype of a satellite pump (with a non-circular tooth working mechanism). In
Śliwiński Paweł
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Optimization of Rotor and Stator Assembly of All-metal Positive Displacement Pump
Shiyou jixie, 2018 In order to determine the optimal clearance of all-metal positive displacement pump rotor and stator, based on the clearance fit feature, a finite element method and the large eddy simulation (LES) model were used to analyze the effect of flow ...
Li Zengliang +5 more
doaj
Designing a New Artificial Lift Method Using Computational Simulation and Evolutionary Optimization
IEEE Access, 2019 Oil exploitation has moved into deeper reservoirs with the advances in drilling techniques and thus the development of new pumping techniques has become a challenge to improve production. The positive displacement pumping system proposed in this paper is
Andre Pimentel Moreira +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Research on a Helmholtz type hydraulic silencer with variable resonance mechanism
Nihon Kikai Gakkai ronbunshu, 2015 Pressure pulsation is caused by the flow ripples from a positive displacement hydraulic pump. It transmits throughout fluid power equipment and causes unwanted excitation of the mechanical parts. In many practical applications, a Helmholtz type hydraulic
Tetsuya KURIBAYASHI +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source