Results 141 to 150 of about 5,504,468 (285)

Research Shows Positive Impacts of Asset Building for Children and Parents [PDF]

open access: yes, 2009
Research findings on asset-building programs, such as Individual Development Accounts (IDAs) for adults and Saving for Education, Entrepreneurship, and Downpayment (SEED) accounts for children, show positive results.

core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

The PERMA - profiler: psychometrics properties among teachers

open access: yesمجله علوم روانشناختی, 2019
Background: Martin M Seligman has developed a multi-dimensional model of Flourishing, PERMA. This model combines positive emotion (hedonic) and positive performance (eudiamonic) dimensions.
Mohammad Hossein Sahrifian   +3 more
doaj  

Happiness Engineering: impact of hope-based intervention on life satisfaction, self-worth, mental health, and academic achievement of Indian school students

open access: yesCogent Education
This research article explores the impact of an intervention aimed at enhancing hope among senior secondary school students. The investigation was carried out in the Bokaro district of Jharkhand, India. The study focuses on the changes observed in scores
Ashraf Alam, Atasi Mohanty
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Commentary: Primary Emotional Systems and Personality: An Evolutionary Perspective

open access: yesFrontiers in Psychology, 2017
Stefano I. Di Domenico   +2 more
doaj   +1 more source

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