Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Diffraction Aided Wireless Positioning [PDF]
Wireless positioning in Non-Line-of-Sight (NLoS) scenarios presents significant challenges due to multipath effects that lead to biased measurements and reduced positioning accuracy. This paper revisits electromagnetic field theory related to diffraction and in the context of wireless positioning and proposes a novel positioning technique that greatly ...
arxiv +1 more source
The effectiveness of teamwork training on teamwork behaviors and team performance : A systematic review and meta-analysis of controlled interventions [PDF]
The objective of this study was to conduct a systematic review and meta-analysis of teamwork interventions that were carried out with the purpose of improving teamwork and team performance, using controlled experimental designs.
Beauchamp, Mark R.+4 more
core +2 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze+3 more
wiley +1 more source
Does Positive Reinforcement Work?: A Quasi-Experimental Study of the Effects of Positive Feedback on Reddit [PDF]
Social media platform design often incorporates explicit signals of positive feedback. Some moderators provide positive feedback with the goal of positive reinforcement, but are often unsure of their ability to actually influence user behavior. Despite its widespread use and theory touting positive feedback as crucial for user motivation, its effect on
arxiv +1 more source
Magnetic Field and Curvature Effects on Pair Production I: Scalars and Spinors [PDF]
The pair production rates for spin-zero and spin-$\frac{1}{2}$ particles are calculated on spaces of the form $M \times {\mathbb R}^{1,1}$ with $M$ corresponding to ${\mathbb R}^2$ (flat), $T^2$ (flat, compactified), $S^2$ (positive curvature) and $H^2$ (
Karabali, D.+2 more
core +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
Background & aim: Currently, with increasing resistance to synthetic drugs, the demand for natural and safe alternatives to these types of medications has increased. Therefore, the aim of the present study was to determine and evaluate the antibacterial
J Sayyahi+3 more
doaj
Significance level and positivity bias as causes for high rate of non-reproducible scientific results? [PDF]
The high fraction of published results that turn out to be incorrect is a major concern of today's science. This paper contributes to the understanding of this problem in two independent directions. First, Johnson's recent claim that hypothesis testing with a significance level of 0.05 can alone lead to an unacceptably large proportion of false ...
arxiv
Will to live in older people’s medical decisions: immediate and delayed effects of aging stereotypes [PDF]
This research explores the duration of age stereotype priming effects on individuals’ will to live when faced with a medical terminal illness decision. Study 1 established the content of the stereotype of the older age group in Portugal. Study 2 tested
Abrams+47 more
core +2 more sources