Results 61 to 70 of about 45,801 (303)

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh, Chaim M. Brickman, Peter Lloyd, Ashish Kalra, Subhabrata Biswas, Arkadeep Sinha, Alex Mulvanny, Sumathi Sivapalasingam, Oren M. Becker, Aaron Deykin   +9 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Variability in expiratory flow requirements among oscillatory positive expiratory pressure

Canadian Journal of Respiratory Therapy, 2020
Introduction Oscillatory positive expiratory pressure (OPEP) devices facilitate secretion clearance by generating positive end expiratory pressure.
Morgan Sherwin E., Mosakowski Steven, Giles Brenda L., Naureckas Edward, Tung Avery   +4 more
doaj   +1 more source

Efek Pemberian Positive End Expiratory Pressure 5 cmH2O terhadap Perubahan Nilai Forced Expiratory Volume in 1 Second dan Forced Vital Capacity pada Pasien Pascaoperasi Ortopedi [PDF]

, 2022
Mohamad Rizki Dwikane, Ezra Oktaliansah, Dhany Budipratama   +2 more
openalex   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source

Application of positive end expiratory pressure during laparoscopic surgery [PDF]

Korean Journal of Anesthesiology, 2013
Hong-Beom Bae
doaj   +1 more source

Effects of the positive end-expiratory pressure increase on sublingual microcirculation in patients with acute respiratory distress syndrome

Revista Brasileira de Anestesiologia
Objective: The aim of this study was to evaluate the impact of increased positive end-expiratory pressure on the sublingual microcirculation. Methods: Adult patients who were sedated, under mechanical ventilation, and had a diagnosis of circulatory ...
Nathaly Fonseca Nunes, Antônio Tonete Bafi, Eduardo Souza Pacheco, Luciano Cesar Pontes de Azevedo, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas   +5 more
doaj   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Individualized positive end-expiratory pressure reduces driving pressure in obese patients during laparoscopic surgery under pneumoperitoneum: a randomized clinical trial

Frontiers in Physiology
IntroductionDuring pneumoperitoneum (PNP), airway driving pressure (ΔPRS) increases due to the stiffness of the chest wall and cephalic shift of the diaphragm, which favors atelectasis.
Tiago Batista Xavier, Tiago Batista Xavier, Leonardo Vicente Coelho, Daniel Antonio Lopes Ferreira, José Manuel Cota y Raposeiras, Marcelo Sampaio Duran, Leticia Almeida Silva, Gabriel Casulari da Motta-Ribeiro, Luciana Moisés Camilo, Alysson Roncally Silva Carvalho, Alysson Roncally Silva Carvalho, Pedro Leme Silva   +11 more
doaj   +1 more source

Positive End-expiratory Pressure Titration after Alveolar Recruitment Directed by Electrical Impedance Tomography

Chinese Medical Journal, 2015
Background: Electrical impedance tomography (EIT) is a real-time bedside monitoring tool, which can reflect dynamic regional lung ventilation. The aim of the present study was to monitor regional gas distribution in patients with acute respiratory ...
Yun Long, Da-Wei Liu, Huai-Wu He, Zhan-Qi Zhao   +3 more
doaj   +1 more source