Results 71 to 80 of about 10,495,383 (253)

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Effects of Positive End-Expiratory Pressure and Spontaneous Breathing Activity on Regional Lung Inflammation in Experimental Acute Respiratory Distress Syndrome

, 2019
OBJECTIVES: To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on regional lung inflammation in experimental nonsevere acute respiratory distress syndrome.
Bergamaschi, Alice, Koch, Thea, Bluth, Thomas, Marcos F. Vidal Melo, Huhle, Robert, Kotzerke, Jörg, Herzog, Moritz, Alice Bergamaschi, Luigi Vivona, Michael Andreeff, Rocco, Patricia R M, Andreeff, Michael, Anja Braune, Patricia R. M. Rocco, Thomas Kiss, Scharffenberg, Martin, Robert Huhle, Jörg Kotzerke, Thomas Bluth, Moritz Herzog, Braune, Anja, Herold, Johannes, Vivona, Luigi, Jakob Wittenstein, Johannes Herold, Kiss, Thomas, Martin Scharffenberg, Pelosi, Paolo, Thea Koch, Gama de Abreu, Marcelo, Denz, Axel, Marco Millone, Marcelo Gama de Abreu, Vidal Melo, Marcos F., Paolo Pelosi, Axel Denz, MILLONE, MARCO, Wittenstein, Jakob   +37 more
core   +2 more sources

Positive end-expiratory pressure titrated according to respiratory system mechanics or to ARDSNetwork table did not guarantee positive end-expiratory transpulmonary pressure in acute respiratory distress syndrome

, 2018
Purpose: Pulmonary recruitment and positive end-expiratory pressure (PEEP) titrated according to minimal static elastance of the respiratory system (PEEP Estat,RS ) compared to PEEP set according to the ARDSNetwork table (PEEP ARDSNetwork ) as a strategy
Rocco, Patricia R. M., Krebs, Joerg, Pelosi, Paolo, Hagmann, Michael, Luecke, Thomas   +4 more
core   +1 more source

Application of positive end expiratory pressure during laparoscopic surgery [PDF]

Korean Journal of Anesthesiology, 2013
Hong-Beom Bae
doaj   +1 more source

Effects of Positive End-Expiratory Pressure on Oscillated Volume during High-Frequency Chest Compression in Children with Cystic Fibrosis

Canadian Respiratory Journal, 2003
OBJECTIVE: To investigate the effects of positive end-expiratory pressure (PEEP) on end-expiratory lung volume (EELV) and mean oscillated volume (Vosc) during high frequency chest compression (HFCC).
Cara F Dosman, Peter C Zuberbuhler, Joan I Tabk, Richard L Jones   +3 more
doaj   +1 more source

Compliant hydrogel cuff coating with real‐time pressure monitoring and antibiofilm capabilities for ventilator‐associated pneumonia prophylaxis

BMEMat, EarlyView.
A soft‐compliant hydrogel cuff coating combines real‐time pressure monitoring with intrinsic antibacterial activity for prophylaxis of ventilator‐associated pneumonia. A flexible pressure‐sensing patch is embedded in the coating to enable wireless dynamic monitoring of endotracheal cuff pressure through Bluetooth.
Jin Chai, Yifu Tan, Jiaheng Liang, Shen Liu, Jiabin Zhao, Shanbo Ma, Chunxin Liu, Minghua Du, Mark Selvan, Xiaopeng Shi, Liqiang Song, Peng Li   +11 more
wiley   +1 more source

Emission Reduction Targets Between Strategy and Executive Compensation: Evidence on Symbolic and Substantive Adoption From German Listed Firms

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms increasingly commit to climate targets yet doubts remain about whether such pledges translate into substantive corporate governance or remain symbolic. The study examines how emission reduction targets (ERTs) in sustainability strategies are reflected in compensation among German listed firms.
Victoria Fohrer, Anna‐Sofia Grabowski
wiley   +1 more source

Effects of the positive end-expiratory pressure increase on sublingual microcirculation in patients with acute respiratory distress syndrome

Revista Brasileira de Anestesiologia
Objective: The aim of this study was to evaluate the impact of increased positive end-expiratory pressure on the sublingual microcirculation. Methods: Adult patients who were sedated, under mechanical ventilation, and had a diagnosis of circulatory ...
Nathaly Fonseca Nunes, Antônio Tonete Bafi, Eduardo Souza Pacheco, Luciano Cesar Pontes de Azevedo, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas   +5 more
doaj   +1 more source

Green Finance, Digitalization, and Banks' Sustainable Business Model Innovations Toward Net‐Zero Transitions

Business Strategy and the Environment, EarlyView.
ABSTRACT Financial capital is widely recognized as having the potential to provide investments needed for net‐zero transitions. While recent empirical studies reveal that financial digitalization and fintech have changed Chinese banks' loan portfolios and business models, they stem from credit restrictions on heavily polluting enterprises and from ...
Akihisa Mori
wiley   +1 more source

Individualized positive end-expiratory pressure reduces driving pressure in obese patients during laparoscopic surgery under pneumoperitoneum: a randomized clinical trial

Frontiers in Physiology
IntroductionDuring pneumoperitoneum (PNP), airway driving pressure (ΔPRS) increases due to the stiffness of the chest wall and cephalic shift of the diaphragm, which favors atelectasis.
Tiago Batista Xavier, Tiago Batista Xavier, Leonardo Vicente Coelho, Daniel Antonio Lopes Ferreira, José Manuel Cota y Raposeiras, Marcelo Sampaio Duran, Leticia Almeida Silva, Gabriel Casulari da Motta-Ribeiro, Luciana Moisés Camilo, Alysson Roncally Silva Carvalho, Alysson Roncally Silva Carvalho, Pedro Leme Silva   +11 more
doaj   +1 more source