Results 61 to 70 of about 572,073 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Positive Energy Districts and deep renovation actions to move beyond the 2025 EU Targets

open access: yesTechne, 2022
Starting from selected results of the COST ACTION PED-EU-NET and IEA EBC Annex 83 PEDs, this article presents an overview of the European projects that, in recent years, have made it possible to evolve from the nZEB concept (applied to deep renovation ...
Rosa Romano   +2 more
doaj   +1 more source

Treatment and valorization plants in materials recovery supply chain [PDF]

open access: yes, 2015
Aim of industrial symbiosis is to create synergies between industries in order to exchange resources (by-products, water and energy) through geographic proximity and collaboration [1].
LA MARCA, Floriana
core  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Assessing Positive Energy District Potential: A Case Study in Central Italy

open access: yesEnergies
This study investigates the application of the Positive Energy District paradigm to two existing and morphologically diverse urban districts in Rome: Testaccio and Valco San Paolo.
Giuseppina Ciulla   +7 more
doaj   +1 more source

Analysis and Evaluation of the Feasibility of Positive Energy Districts in Selected Urban Typologies in Vienna Using a Bottom-Up District Energy Modelling Approach

open access: yesEnergies, 2021
This article investigates the potential of selected urban typologies in Vienna to reach the state of Positive Energy Districts (PED) by achieving a positive annual energy balance.
Hans-Martin Neumann   +4 more
doaj   +1 more source

Scotland Chikwawa Health Initiative - improving health from community to hospital [PDF]

open access: yes, 2008
The Scotland Chikwawa Health Initiative is a three year programme funded by the Scottish Executive International Development Fund which aims to achieve measurable reductions in major causes of disease and death in four villages within the Chikwawa ...
Grimason, Anthony   +6 more
core  

Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation [PDF]

open access: yes, 2018
Sounds associated with newly learned information that are replayed during non-rapid eye movement (NREM) sleep can improve recall in simple tasks. The mechanism for this improvement is presumed to be reactivation of the newly learned memory during sleep ...
Diana M. Armstrong   +10 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy