Results 91 to 100 of about 5,703 (300)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Stort er velgjort – eller småt er godt?

open access: yesTidsskrift for Professionsstudier, 2018
Does school closures affect the local social capital? Through a comparative study of school closures in the municipality of Tønder (Ballum and Bedsted), we argue that centralization and school closures can eliminate the positive externality of social ...
Gunnar Lind Haase Svendsen   +1 more
doaj   +1 more source

Neural Positioning Without External Reference

open access: yesCoRR
Submitted to a ...
Till-Yannic Müller   +4 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

An empirical study on the positive externality of building refurbishment

open access: yes, 2008
Purpose – The paper's objective is to empirically study the effects of building refurbishment on the prices of the dwelling units in a contiguous housing estate in Hong Kong.
Wong, SK, Yau, Y, Chau, KW, Ho, DCW
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Strategic choice of KOL and AI live-streaming considering network externality of differentiated firms

open access: yesJournal of Management Science and Engineering
The rapid development of network technology and live-streaming sales has facilitated the emergence of artificial intelligence digital human (AI) live-streaming technology, posing new challenges to traditional key opinion leader (KOL) live-streaming ...
Pingping Chen   +3 more
doaj   +1 more source

Individual freedom versus collective responsibility: an economic epidemiology perspective

open access: yesEmerging Themes in Epidemiology, 2006
Individuals' free choices in vaccination do not guarantee social optimum since individuals' decision is based on imperfect information, and vaccination decision involves positive externality.
Sadique M Zia
doaj   +1 more source

A Non-cooperative Foundation of Core-Stability in Positive Externality NTU-Coalition Games [PDF]

open access: yes
We identify the core as an appealing stability concept of cooperative game theory, but argue that the non-cooperative approach has conceptual advantages in the context of economic problems with externalities.
Michael Finus, Bianca Rundshagen
core  

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